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Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition) ›› 2025, Vol. 11 ›› Issue (01): 27-30. doi: 10.3877/cma.j.issn.2096-1537.2025.01.006

• Editorials • Previous Articles     Next Articles

Severe infections and immune dysfunction:progress and prospects 2024

Jianfeng Wu1, Fei Pei1, Xiangdong Guan1,()   

  1. 1. Department of Critical Care Medicine,the First Affiliated Hospital,Sun Yat-sen University,Guangdong Clinical Research Center for Critical Care Medicine,Guangzhou 510080,China
  • Received:2025-02-14 Online:2025-02-28 Published:2025-04-22
  • Contact: Xiangdong Guan

Abstract:

Sepsis,as a major challenge in critical care medicine,is fundamentally characterized by dysregulated host immune response. This paper elucidates the latest research advancements from the following four perspectives:mechanisms of host immune response dysregulation,new methods for immune monitoring,precision immunotherapy strategies,and the developmental prospects of a stepwise approach to precision treatment in sepsis. This review summarizes current progress in sepsis immunotherapy,explores its challenges and opportunities,and provides new insights for precision immunotherapy in sepsis.

Key words: Sepsis, Immune dysregulation, Immunotherapy, Precision treatment

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