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Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition) ›› 2025, Vol. 11 ›› Issue (01): 100-104. doi: 10.3877/cma.j.issn.2096-1537.2025.01.019

• Reviews • Previous Articles    

Advance in effect of crystalloids on acute kidney injury in patients with septic shock

Ran Wang1, Wei Chang1, Yi Yang1, Jingyuan Xu1,()   

  1. 1. Department of Critical Care Medicine,Jiangsu Provincial Key Laboratory of Critical Care Medicine,Zhongda Hospital,School of Medicine,Southeast University,Nanjing 210009,China
  • Received:2023-12-03 Online:2025-02-28 Published:2025-04-22
  • Contact: Jingyuan Xu

Abstract:

Fluid resuscitation plays an important role in the treatment of septic shock. For adults with sepsis or septic shock,crystalloid is recommended as first-line fluid for resuscitation in the latest Surviving Sepsis Campaign guidelines. The specific type of crystalloid given is still controversial. Saline is prone to hyperchloremia due to high chloride concentration and has adverse effects on the renal function. Balanced crystalloids are of interest to clinicians because their composition are closer to extracellular fluid of human body. In this paper,the advantages and disadvantages of different crystalloids and their selection were summarized based on the research of the influence of crystalloids on acute kidney injury in patients with septic shock in recent years.

Key words: Septic shock, Acute kidney injury, Fluid resuscitation, Crystalloid

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