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Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition) ›› 2025, Vol. 11 ›› Issue (04): 397-401. doi: 10.3877/cma.j.issn.2096-1537.2025.04.010

• Review • Previous Articles    

Research progress of methylene blue in septic shock

Zhu Luo, Yichun Sun, Jingyuan Xu()   

  1. Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Clinical Medicine, Southeast University, Nanjing 210009, China
  • Received:2024-04-25 Online:2025-11-28 Published:2026-03-24
  • Contact: Jingyuan Xu

Abstract:

Septic shock is one of the most important threats to human life and health. Despite ongoing researches, the morbidity and mortality remain high. As a non-catecholamine-based vasoconstrictor, methylene blue has been shown in many studies to increase mean arterial pressure, reduce the need of catecholamine vasopressors and reduce the mortality of septic shock. However, these findings have not been consistently conclusive. This article reviewed the therapeutic effect of methylene blue in septic shock in this manuscript.

Key words: Septic shock, Methylene blue, Treatment

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