The definition of sepsis has remained largely unchanged for the last twenty years since its release in 1992 and update in 2001. Sepsis-3 task force has recently redefined sepsis and published new clinical diagnostic criteria based on the latest analysis of large clinical database. However, organ dysfunction, which has been defined as nature of sepsis, is self-contradictory. The SOFA criteria is facing the same problem with SIRS criteria. Tough problems are still existing with sepsis. It is not wise to change the present definition/clinical criteria framework when we are not wise enough to make a major breakthrough in the pathophysiology of sepsis.