Recent studies using bedside ultrasound images have revealed that sepsis-induced cardiac diastolic dysfunction is a common clinical phenomenon. Increasing evidence suggests that excessive adrenergic stress, inflammatory injury and inadequate fluid resuscitation may all contribute to sepsis-induced cardiac diastolic dysfunction although the exact mechanisms remain unclear. The current approaches of clinical interventions are controversial making it difficult to reach a consensus for recommended guidelines. Further basic research and clinical investigation is urgently required to improve the management of sepsis-induced cardiac diastolic dysfunction in critically ill patients.