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Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition) ›› 2017, Vol. 03 ›› Issue (01): 33-39. doi: 10.3877/cma.j.issn.2096-1537.2017.01.008

Special Issue: Critical care medicine

• Opinion • Previous Articles     Next Articles

Can biomarkers help early diagnosis of acute kidney injury?

Hao Tang1, Dongpo Jiang1,()   

  1. 1. Intensive Care Unit, State Key Laboratory of Trauma, Burn and Combined Injury, Army War Trauma Center of Field Surgery Institute, Daping Hospital, Third Military Medical University, Chongqing 40042, China
  • Received:2017-01-18 Online:2017-02-28 Published:2017-02-28
  • Contact: Dongpo Jiang
  • About author:
    Jiang Dongpo, Email:

Abstract:

Despite recent developments in definition and staging of acute kidney injury (AKI), the diagnosis of AKI is still based on oliguria and/or an increase in serum creatinine concentration. Consequently, research in the last decade has focused on the discovery and validation of more specific and sensitive biomarkers of tubular damage and functional impairment. The most advanced biomarkers promise to identify patients at risk of AKI, diagnose AKI earlier than conventional tests, predict the risk of progression, including need for renal replacement therapy (RRT) and improve the prognosis. This review summarizes the important biomarkers identified by previous studies and aims to highlight the advancements that might provide new evidence for early clinical diagnosis and effective therapeutic options.

Key words: Acute kidney injury, Biological markers, Diagnosis

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