Effects of post-splenectomy analgesia on cytokines in trumatic splenic rupture patients

doi:10.3877/cma.j/jssn.2096-1537.2017.01.010

Abstract

Abstract:

Objective

To observe the effects of post-splenectomy analgesia on cytokines in traumatic splenic rupture patients.

Methods

44 cases of traumatic splenic rupture patients who underwent splenectomy were randomized into two groups, analgesic group was being infused with sufentanil for postoperative analgesia, while the control group was being infused with normal saline. The analgesic effects of each group were recorded with visual analog score (VAS) andserum concentration of IL-6, TNF-α, IL-4, and IL-10 were measured by ELISA before operation, after operation, at postoperative 12 h, postoperative 24 h, and postoperative 48 h in both groups.

Results

The VAS were lower than in the control group at each evaluating time point (t=-3.218, -3.615, -1.458, -2.773, -0.483, all P<0.05). Serum concentration of IL-6, TNF-α, IL-4, and IL-10 in the control group in time point postoperative 12 h, postoperative 24 h, and postoperative 48 h were higher than those in the analgesia group (IL-6: t=-3.556, -6.020, -3.471; TNF-α: t=-2.146, -3.874, -2.778; IL-4: t=-4.975, -2.322, -0.604; IL-10: t=-6.090, -4.340, -2.773, all P<0.05).

Conclusion

Effective analgesia can alleviate immune injury and inflammation after splenectomy in traumatic splenic rupture patients.

Key words: Analgesia, Splenectomy, Immune

Tao Tu, Jin Wang. Effects of post-splenectomy analgesia on cytokines in trumatic splenic rupture patients[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2017, 03(01): 46-49.

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URL: https://icu.cma-cmc.com.cn/EN/10.3877/cma.j/jssn.2096-1537.2017.01.010

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组别	例数	ASA分级（Ⅰ/Ⅱ）	性别（男/女）	年龄（岁，±s）	病程（d，±s）	手术时间（h，±s）
镇痛组	25	13/12	17/8	43.2±6.5	0.65±0.10	1.1±0.3
对照组	19	10/9	13/6	42.9±7.1	0.71±0.20	1.0±0.2
统计值		χ²=0.002	χ²=0.000	t=0.146	t=1.304	t=1.252
P值		0.967	0.976	0.885	0.199	0.217

组别	例数	ASA分级（Ⅰ/Ⅱ）	性别（男/女）	年龄（岁，±s）	病程（d，±s）	手术时间（h，±s）
镇痛组	25	13/12	17/8	43.2±6.5	0.65±0.10	1.1±0.3
对照组	19	10/9	13/6	42.9±7.1	0.71±0.20	1.0±0.2
统计值		χ²=0.002	χ²=0.000	t=0.146	t=1.304	t=1.252
P值		0.967	0.976	0.885	0.199	0.217

组别	例数	VAS评分
组别	例数	术后4 h	术后8 h	术后12 h	术后24 h	术后48 h
镇痛组	25	3.5±1.4	3.1±1.2	2.9±1.0	2.4±0.7	1.6±0.5
对照组	19	7.3±1.8	7.0±1.4	4.8±1.1	4.5±0.5	1.8±0.6
t值		-3.218	-3.615	-1.458	-2.773	-0.483
P值		0.004	0.003	0.036	0.024	0.642

组别	例数	VAS评分
组别	例数	术后4 h	术后8 h	术后12 h	术后24 h	术后48 h
镇痛组	25	3.5±1.4	3.1±1.2	2.9±1.0	2.4±0.7	1.6±0.5
对照组	19	7.3±1.8	7.0±1.4	4.8±1.1	4.5±0.5	1.8±0.6
t值		-3.218	-3.615	-1.458	-2.773	-0.483
P值		0.004	0.003	0.036	0.024	0.642

组别	例数	血浆IL-6
组别	例数	术前	术毕	术后12 h	术后24 h	术后48 h
镇痛组	25	34.6±10.5	39.6±11.2	42.9±12.4	45.3±10.9	33.7±9.4
对照组	19	35.2±11.6	40.8±11.7	51.7±12.1	70.2±14.1	42.2±11.3
t值		-0.613	-0.672	-3.556	-6.020	-3.471
P值		0.568	0.581	0.023	0.000	0.026

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