Abdominal compartment syndrome secondary to hyperlipidemia pancreatitis induce high morbidity and mortality. Numerous experimental and clinical studies have been conducted in abdominal compartment syndrome secondary to hyperlipidemia pancreatitis. However, the risk factors and therapeutic options remain unclear and controversial. In this editorial article, we will summarize the findings of previous studies and discuss the morbidity, risk factors, diagnosis and potential therapeutic recommendation in abdominal compartment syndrome secondary to hyperlipidemia pancreatitis, aim to promote the further basic and clinical study.