In the neuro-intensive care unit, the surgical strikes and numerous invasive procedures make patients feel pain, agitation and activation, which results in hypertension and increased heart rates. This will increase the risk of rebleeding, intracranial hypertension, unexpectedly extubation, accidentally injures and so on. Sedation and analgesia play a critical role in protecting brain through pain and discomfort relieve, decreasing the stress and reducing brain metabolism to prevent intracranial hypertension and hypertension. We will review the impact of the therapy of analgesia and sedation in patients with craniocerebral injury in this paper.