Some thoughts on metagenomics next-generation sequencing technology for early anti-infection targeted therapy of severe infections

doi:10.3877/cma.j.issn.2096-1537.2022.04.001

Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition) ›› 2022, Vol. 08 ›› Issue (04): 289-290. doi: 10.3877/cma.j.issn.2096-1537.2022.04.001

Special Issue: Critical care medicine；

• Editorial • Next Articles

Some thoughts on metagenomics next-generation sequencing technology for early anti-infection targeted therapy of severe infections

Xiang Yang¹, Haibo Qiu²^,^†()

^1. Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China; Department of Geriatrics, Genernal Hospital of Eastern Theater Command, PLA, Nanjing 210002, China
^2. Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China

Received:2022-08-25 Online:2022-11-28 Published:2023-02-07
Contact: Haibo Qiu

Abstract

Abstract:

Early effective and accurate antibiotic therapy is the key to reduce mortality of patients with severe infections. Identification of pathogenic microorganism is essential for appropriate antibiotic therapy. Metagenomics next generation sequencing (mNGS) is a novel pathogenic, diagnostic technology with fast detection speed, high accuracy, and comprehensive coverage. mNGS has been used to diagnose specific pathogenic microbial infections in recent years. However, many problems still need to be solved in the early target anti-microbial therapy of severe infections. This paper summarizes several problems that need to be considered in the use of mNGS in severe cases.

Key words: Metagenomics next generation sequencing, Severe infection, Targeted therapy

Xiang Yang, Haibo Qiu. Some thoughts on metagenomics next-generation sequencing technology for early anti-infection targeted therapy of severe infections[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2022, 08(04): 289-290.

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