Disease burden and current research status in sepsis with chronic comorbidities

doi:10.3877/cma.j.issn.2096-1537.2026.01.002

Abstract

Abstract:

Sepsis is a life-threatening clinical syndrome with a high mortality rate globally. Chronic comorbidities are important factors influencing the clinical course and prognosis of sepsis. Chronic comorbidities are highly prevalent among sepsis patients, and those with chronic diseases exhibit relatively distinct physiological characteristics in immune response and vascular function. Moreover, patients with chronic comorbidities face higher mortality and poorer quality of life. In terms of treatment, uncertainty remains regarding the management of sepsis in patients with different types of comorbidities, particularly concerning anti-infection treatment, fluid resuscitation, and multiorgan support. Meanwhile, active and continuous post-ICU management is of great value. This review summarizes the disease burden and current research status of sepsis in patients with chronic comorbidities, aiming to provide a theoretical basis and reference for future mechanistic researches and precision treatment.

Key words: Sepsis, Chronic disease, Prognosis, Treatment

Nan Shi, Ruixuan Yu, Jianfeng Xie, Haibo Qiu. Disease burden and current research status in sepsis with chronic comorbidities[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2026, 12(01): 7-14.

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