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中华重症医学电子杂志 ›› 2021, Vol. 07 ›› Issue (02): 174 -179. doi: 10.3877/cma.j.issn.2096-1537.2021.02.015

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细胞外囊泡在急性呼吸窘迫综合征中潜在作用的研究进展
王皓飞 1, 黄英姿 1 , ( )   
  1. 1. 210009 南京,江苏省重症医学重点实验室 东南大学附属中大医院重症医学科
  • 收稿日期:2020-11-06 出版日期:2021-05-28
  • 通信作者: 黄英姿
  • 基金资助:
    国家自然科学基金资助项目(81971812); 江苏省自然科学基金项目(BK20191264)

Potential role of extracellular vesicles in acute respiratory distress syndrome

Haofei Wang 1, Yingzi Huang 1( )   

  1. 1. Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, the Affiliated Hospital of Southeast University, Nanjing 210009, China
  • Received:2020-11-06 Published:2021-05-28
  • Corresponding author: Yingzi Huang

急性呼吸窘迫综合征(ARDS)是由肺和肺外多种损伤引起的危及生命的疾病,其病死率居高不下,发病机制仍需进一步阐明。近些年的研究表明,失衡的免疫应答在ARDS的发生发展中起重要作用。细胞外囊泡(EVs)是一种细胞分泌的小的无核细胞结构,可以在多种细胞类型间靶向转移多种生物物质,在细胞通讯及物质传递方面起重要作用。近年来对EVs的研究为阐明ARDS的发病机制及其治疗提供了新的思路。本文就EVs在ARDS中的潜在的生物标志物作用和治疗作用的研究进展作一综述,提出不同细胞来源的EVs可能作为ARDS早期识别的生物标志物以及临床治疗的新方向。

Acute respiratory distress syndrome (ARDS) is a life-threatening syndrome caused by pulmonary and extrapulmonary injury. The mortality remains high and the pathogenesis still needs to be further clarified. Recent studies have shown that imbalanced immune responses play an important role in the occurrence and development of ARDS. Extracellular vesicles (EVs) are small non-nucleated cell structures secreted by cells, which can target and transfer a variety of biological substances among various cell types, and play an important role in cell communication and material transfer. In recent years, research on EVs has provided new ideas for the pathogenesis and treatment of ARDS. We review the progress of potential biomarkers and therapeutic effects of EVs in ARDS, and proposes that EVs from different cell sources may be used as biomarkers for early recognition and new management target in ARDS in this manuscript.

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