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中华重症医学电子杂志 ›› 2021, Vol. 07 ›› Issue (02) : 169 -173. doi: 10.3877/cma.j.issn.2096-1537.2021.02.014

综述

脓毒症休克的诊治在精准医学时代下的发展及临床应用
张璐1, 李响1,(), 夏世宏1, 童琦1, 孙英杰1, 马雪丽1   
  1. 1. 201199 上海,复旦大学附属闵行医院重症监护室
  • 收稿日期:2020-09-29 出版日期:2021-05-28
  • 通信作者: 李响

Development and clinical application of the diagnosis and treatment of septic shock in the era of precision medicine

Lu Zhang1, Xiang Li1,(), Shihong Xia1, Qi Tong1, Yingjie Sun1, Xueli. Ma1   

  1. 1. Department of Intensive Care Unit, Minhang Hospital, Fudan University, Shanghai 201199, China
  • Received:2020-09-29 Published:2021-05-28
  • Corresponding author: Xiang Li
引用本文:

张璐, 李响, 夏世宏, 童琦, 孙英杰, 马雪丽. 脓毒症休克的诊治在精准医学时代下的发展及临床应用[J]. 中华重症医学电子杂志, 2021, 07(02): 169-173.

Lu Zhang, Xiang Li, Shihong Xia, Qi Tong, Yingjie Sun, Xueli. Ma. Development and clinical application of the diagnosis and treatment of septic shock in the era of precision medicine[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2021, 07(02): 169-173.

脓毒症休克病情凶险,致死率高。精准医学作为新型医学概念,其医疗模式影响了众多肿瘤及慢性病患者,也为脓毒症的精确诊治带来曙光。同时临床操作技术、基因检测、分子生物学的发展为脓毒症的精准诊治提供了数据和信息,通过对脓毒症患者不同病理生理状态、生物标志物、病原学、基因组学的分析与鉴定来进行个性化精准诊治。本文就精准医学在脓毒症休克诊治中取得的进展进行综述,并对这种新医疗模式的未来进行展望。

Septic shock is a critical condition with high mortality. Precision medicine as a new medical concept has affected cancer and chronic disease patients which also bring the hope for the accurate diagnosis and treatment in patients with sepsis. The development of clinical operation technology, gene detection and molecular biology provides data and information for the accurate diagnosis and treatment of sepsis, and promotes the progress and innovation of the diagnosis and treatment. Personalized and accurate management can be perfomed according to different pathophysiological status, biomarkers, etiology, genomics and other aspects. We review the progress of precision medicine in the diagnosis and treatment of sepsis, and prospects the future of this new medical model.

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