切换至 "中华医学电子期刊资源库"

第五届中国出版政府奖音像电子网络出版物奖提名奖

中国科技核心期刊

中国科学引文数据库(CSCD)来源期刊

中华重症医学电子杂志 ›› 2021, Vol. 07 ›› Issue (03) : 277 -281. doi: 10.3877/cma.j.issn.2096-1537.2021.03.015

综述

几丁质酶-3样蛋白-1在感染性疾病中的研究进展
李福星1, 李菊香2,()   
  1. 1. 360006 南昌大学第二附属医院重症医学科
    2. 360006 南昌大学第二附属医院心血管内科
  • 收稿日期:2020-12-01 出版日期:2021-08-28
  • 通信作者: 李菊香
  • 基金资助:
    江西省自然科学基金面上项目(20202BAB206058)

Progress in study of chitinase-3-like protein-1 in infectious diseases

Fuxing Li1, Juxiang Li2,()   

  1. 1. Department of Critical Care Medicine, the Second Affiliated Hospital of Nanchang University, Nanchang 360006, China
    2. Department of Cardiovascular Medicine, the Second Affiliated Hospital of Nanchang University, Nanchang 360006, China
  • Received:2020-12-01 Published:2021-08-28
  • Corresponding author: Juxiang Li
引用本文:

李福星, 李菊香. 几丁质酶-3样蛋白-1在感染性疾病中的研究进展[J/OL]. 中华重症医学电子杂志, 2021, 07(03): 277-281.

Fuxing Li, Juxiang Li. Progress in study of chitinase-3-like protein-1 in infectious diseases[J/OL]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2021, 07(03): 277-281.

几丁质酶-3样蛋白-1(CHI3L1)在原核生物和真核生物中普遍存在,由多种细胞分泌,在哮喘、脓毒症、类风湿关节炎、冠状动脉病变等多种炎症疾病状态下可观察到CHI3L1的过表达。近20年,随着对CHI3L1在不同疾病中作用机制的不断探索及临床研究的逐渐深入,其重要性日益受到关注。本文就CHI3L1在各种急性感染中,特别是重症感染中的研究进展作一综述,以期对未来脓毒症的基础研究和临床研究有所启发。

Chitinase-3 like-protein-1 (CHI3L1) is commonly expressed in prokaryote and eukaryote, and can be secreted by a multitude of cells. It has been observed that CHI3L1 is overexpressed in numerous inflammatory disease states including asthma, sepsis, rheumatoid arthritis, coronary artery disease and so on. In the last two decades, its has attracted more and more attention with continuous exploration of its mechanism in different diseases and gradual deepening of clinical researchs. This article reviewed the research progress of CHI3L1 in various acute infections, especially severe infections, in order to promote the basic and clinical research of sepsis in the future.

1
Di Rosa M, Distefano G, Zorena K, et al. Chitinases and immunity: Ancestral molecules with new functions [J]. Immunobiology, 2016, 221(3): 399-411.
2
Hakala BE, White C, Recklies AD. Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family [J]. J Biol Chem, 1993, 268(34): 25803-25810.
3
Dela Cruz CS, Liu W, He CH, et al. Chitinase 3-like-1 promotes Streptococcus pneumoniae killing and augments host tolerance to lung antibacterial responses [J]. Cell Host Microbe, 2012,12(1): 34-46.
4
Schmidt IM, Hall IE, Kale S, et al. Chitinase-like protein Brp-39/YKL-40 modulates the renal response to ischemic injury and predicts delayed allograft function [J]. J Am Soc Nephrol, 2013, 24(2): 309-319.
5
Xu N, Bo Q, Shao R, et al. Chitinase-3-like-1 promotes M2 macrophage differentiation and induces choroidal neovascularization in neovascular age-related macular degeneration [J]. Invest Ophthalmol Vis Sci, 2019, 60(14): 4596-4605.
6
Bara I, Ozier A, Girodet PO, et al. Role of YKL-40 in bronchial smooth muscle remodeling in asthma [J]. Am J Respir Crit Care Med, 2012, 185(7): 715-722.
7
Zheng JL, Lu L, Hu J, et al. Increased serum YKL-40 and C-reactive protein levels are associated with angiographic lesion progression in patients with coronary artery disease [J]. Atherosclerosis, 2010, 210(2): 590-595.
8
Hattori N, Oda S, Sadahiro T, et al. YKL-40 identified by proteomic analysis as a biomarker of sepsis [J]. Shock, 2009, 32(4): 393-400.
9
Rathcke CN, Vestergaard H. YKL-40--an emerging biomarker in cardiovascular disease and diabetes [J]. Cardiovasc Diabetol, 2009, 8: 61.
10
Nordenbaek C, Johansen JS, Junker P, et al. YKL-40, a matrix protein of specific granules in neutrophils, is elevated in serum of patients with community-acquired pneumonia requiring hospitalization [J]. J Infect Dis, 1999, 180(5): 1722-1726.
11
Wang HL, Hsiao PC, Tsai HT, et al. Usefulness of plasma YKL-40 in management of community-acquired pneumonia severity in patients [J]. Int J Mol Sci, 2013, 14(11): 22817-22825.
12
Spoorenberg SM, Vestjens SM, Rijkers GT, et al. YKL-40, CCL18 and SP-D predict mortality in patients hospitalized with community-acquired pneumonia [J]. Respirology, 2017, 22(3): 542-550.
13
Spoorenberg SMC, Vestjens SMT, Voorn GP, et al. Course of SP-D, YKL-40, CCL18 and CA 15-3 in adult patients hospitalised with community-acquired pneumonia and their association with disease severity and aetiology: A post-hoc analysis [J]. PLoS One, 2018, 13(1): e0190575.
14
Jang YY, Park HJ, Chung HL. Serum YKL-40 levels may help distinguish exacerbation of post-infectious bronchiolitis obliterans from acute bronchiolitis in young children [J]. Eur J Pediatr, 2017, 176(7): 971-978.
15
Yang X, Sheng G. YKL-40 levels are associated with disease severity and prognosis of viral pneumonia, but not available in bacterial pneumonia in children [J]. BMC Pediatr, 2018, 18(1): 381.
16
Sawatzky J, Soo J, Conroy AL, et al. Biomarkers of systemic inflammation in ugandan infants and children hospitalized with respiratory syncytial virus infection [J]. Pediatr Infect Dis J, 2019, 38(8): 854-859.
17
Fantino E, Gangell CL, Hartl D, et al. Airway, but not serum or urinary, levels of YKL-40 reflect inflammation in early cystic fibrosis lung disease [J]. BMC Pulm Med, 2014, 14: 28.
18
Johansen JS, Krabbe KS, Møller K, et al. Circulating YKL-40 levels during human endotoxaemia [J]. Clin Exp Immunol, 2005, 140(2): 343-348.
19
Kronborg G, Ostergaard C, Weis N, et al. Serum level of YKL-40 is elevated in patients with Streptococcus pneumoniae bacteremia and is associated with the outcome of the disease [J]. Scand J Infect Dis, 2002, 34(5): 323-326.
20
Kornblit B, Hellemann D, Munthe-Fog L, et al. Plasma YKL-40 and CHI3L1 in systemic inflammation and sepsis-experience from two prospective cohorts [J]. Immunobiology, 2013, 218(10): 1227-1234.
21
Maddens B, Ghesquière B, Vanholder R, et al. Chitinase-like proteins are candidate biomarkers for sepsis-induced acute kidney injury [J]. Mol Cell Proteomics, 2012, 11(6): M111.013094.
22
Kim HH, Chung MH, Bin JH, et al. Urinary YKL-40 as a candidate biomarker for febrile urinary tract infection in young children [J]. Ann Lab Med, 2018, 38(1): 39-45.
23
Østergaard C, Johansen JS, Benfield T, et al. YKL-40 is elevated in cerebrospinal fluid from patients with purulent meningitis [J]. Clin Diagn Lab Immunol, 2002, 9(3): 598-604.
24
Erturk A, Cure E, Cure MC, et al. The association between serum YKL-40 levels, mean platelet volume, and c-reactive protein in patients with cellulitis [J]. Indian J Med Microbiol, 2015, 33(Suppl): 61-66.
25
Kjaergaard AD, Helby J, Johansen JS, et al. Elevated plasma YKL-40 and risk of infectious disease: a prospective study of 94665 individuals from the general population [J]. Clin Microbiol Infect, 2020, 26(10): 1411.e1-1411.e9.
26
Karwelat D, Schmeck B, Ringel M, et al. Influenza virus-mediated suppression of bronchial Chitinase-3-like 1 secretion promotes secondary pneumococcal infection [J]. FASEB J, 2020, 34(12): 16432-16448.
27
Gao N, Yu FS. Chitinase 3-like 1 promotes candida albicans killing and preserves corneal structure and function by controlling host antifungal responses [J]. Infect Immun, 2015, 83(10): 4154-4164.
28
黄丽林, 张静, 高文超, 等. 类几丁质酶3蛋白1在申克孢子丝菌刺激巨噬细胞的表达和作用研究 [J]. 中国人兽共患病学报, 2015, 31(10): 938-942.
29
Mizoguchi E. Chitinase 3-like-1 exacerbates intestinal inflammation by enhancing bacterial adhesion and invasion in colonic epithelial cells [J]. Gastroenterology, 2006, 130(2): 398-411.
30
Kawada M, Chen CC, Arihiro A, et al. Chitinase 3-like-1 enhances bacterial adhesion to colonic epithelial cells through the interaction with bacterial chitin-binding protein [J]. Lab Invest, 2008, 88(8): 883-895.
31
Chen CC, Llado V, Eurich K, et al. Carbohydrate-binding motif in chitinase 3-like 1 (CHI3L1/YKL-40) specifically activates Akt signaling pathway in colonic epithelial cells [J]. Clin Immunol, 2011, 140(3): 268-275.
32
Low D, Tran HT, Lee IA, et al. Chitin-binding domains of Escherichia coli ChiA mediate interactions with intestinal epithelial cells in mice with colitis [J]. Gastroenterology, 2013, 145(3): 602-612.e619.
33
Tran HT, Lee IA, Low D, et al. Chitinase 3-like 1 synergistically activates IL6-mediated STAT3 phosphorylation in intestinal epithelial cells in murine models of infectious colitis [J]. Inflamm Bowel Dis, 2014, 20(5): 835-846.
34
Bohr S, Patel SJ, Vasko R, et al. The role of CHI3L1 (Chitinase-3-like-1) in the pathogenesis of infections in burns in a mouse model [J]. PLoS One, 2015, 10(11): e0140440.
35
Zhang JJ, Zhang N, Wu W, et al. MicroRNA-24 modulates Staphylococcus aureus-induced macrophage polarization by suppressing CHI3L1 [J]. Inflammation, 2017, 40(3): 995-1005.
36
Chen X, Jiao J, He X, et al. CHI3L1 regulation of inflammation and the effects on osteogenesis in a Staphylococcus aureus-induced murine model of osteomyelitis [J]. FEBS J, 2017, 284(11): 1738-1747.
37
Kim MJ, Shim DH, Cha HR, et al. Chitinase 3-like 1 protein plays a critical role in respiratory syncytial virus-induced airway inflammation [J]. Allergy, 2019, 74(4): 685-697.
38
Li F, Sheng Z, Lan H, et al. Downregulated CHI3L1 alleviates skeletal muscle stem cell injury in a mouse model of sepsis [J]. IUBMB Life, 2020, 72(2): 214-225.
[1] 庄燕, 戴林峰, 张海东, 陈秋华, 聂清芳. 脓毒症患者早期生存影响因素及Cox 风险预测模型构建[J/OL]. 中华危重症医学杂志(电子版), 2024, 17(05): 372-378.
[2] 杨瑾, 刘雪克, 张媛媛, 金钧, 韦瑶. 肠道微生物来源石胆酸对脓毒症相关肝损伤的保护作用[J/OL]. 中华危重症医学杂志(电子版), 2024, 17(04): 265-274.
[3] 张霞, 张瑞, 郑志波, 张勤. 紫草素调控乳酸化修饰和线粒体功能改善脓毒症心肌病小鼠的预后[J/OL]. 中华危重症医学杂志(电子版), 2024, 17(04): 275-284.
[4] 张婧琦, 江洋, 孙佳璐, 唐兴喆, 赵宇飞, 崔颖, 李信响, 戴景月, 傅琳, 彭新桂. 基于肾周CT特征结合血清肌酐水平探讨脓毒症伴急性肾损伤的早期识别[J/OL]. 中华危重症医学杂志(电子版), 2024, 17(04): 285-292.
[5] 李振翮, 魏长青, 甄国栋, 李振富. 脓毒症并发急性呼吸窘迫综合征患者血清S1P、Wnt5a变化及其临床意义[J/OL]. 中华危重症医学杂志(电子版), 2024, 17(04): 293-300.
[6] 樊恒, 孙敏, 朱建华. 红景天苷通过抑制PI3K/AKT/mTOR信号通路对大鼠脓毒症急性肾损伤的保护作用[J/OL]. 中华危重症医学杂志(电子版), 2024, 17(03): 188-195.
[7] 姜珊, 李湘燕, 田硕涵, 温冰, 何睿, 齐心. 采用优化抗感染治疗模式改善糖尿病足感染预后的临床观察[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(05): 398-403.
[8] 成人脓毒症患者β-内酰胺类抗生素延长输注专家共识编写组. 成人脓毒症患者β-内酰胺类抗生素延长输注专家共识[J/OL]. 中华重症医学电子杂志, 2024, 10(04): 313-324.
[9] 陈曦, 吴宗盛, 郑明珠, 邱海波. 胸腺萎缩在脓毒症免疫紊乱中的研究进展[J/OL]. 中华重症医学电子杂志, 2024, 10(04): 379-383.
[10] 杨翔, 郭兰骐, 谢剑锋, 邱海波. 转录组学在脓毒症诊疗中的临床研究进展[J/OL]. 中华重症医学电子杂志, 2024, 10(04): 384-388.
[11] 胡梓菡, 彭菲, 孙骎, 杨毅. 细胞外囊泡在脓毒症血管内皮损伤作用中的研究进展[J/OL]. 中华重症医学电子杂志, 2024, 10(03): 265-270.
[12] 刘娟丽, 马四清, 乌仁塔娜. 髓源性抑制细胞在脓毒症中的研究进展[J/OL]. 中华重症医学电子杂志, 2024, 10(03): 271-278.
[13] 陈惠英, 邱敏珊, 邵汉权. 脓毒症诱发肠黏膜屏障功能损伤的风险因素模型构建与应用效果[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(05): 448-452.
[14] 傅新露, 李之岳, 卢丹. 妊娠合并结肠癌穿孔致脓毒症休克一例并文献复习[J/OL]. 中华产科急救电子杂志, 2024, 13(04): 227-231.
[15] 席静妮, 李娜, 张琪. 中性粒细胞与淋巴细胞比值对老年重症社区获得性肺炎进展为脓毒症的预测价值[J/OL]. 中华老年病研究电子杂志, 2024, 11(03): 28-31.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?