Sever heat stroke, a life-threatening condition with high mortality and disability, is often accompanied withby multi-organ dysfunction syndrome (MODS). Cardiovascular dysfunction is common in heatstroke patients with multiple organ dysfunction syndrome. At present, the lack of understanding of its pathophysiological mechanism of cardiac dysfunction, is the main reason why there is insufficient prevention and treatment strategies for heat-induced cardiac dysfunction. Therefore, we provide a comprehensive review of recent advances in the cardiovascular dysfunction, heart injury and related molecular biological mechanism in heat stroke, aims to better understand the cardiac dysfunction caused by heat stroke and provide ideas for clinical effective treatment.