The role of macrophage polarization in the immune mechanism of sepsis

doi:10.3877/cma.j.issn.2096-1537.2019.02.018

Abstract

Abstract:

Sepsis is a syndrome of immune response caused by infection, resulting in multiple organ dysfunction. Macrophages, as one of the important components of innate and adaptive immunity, can differentiate into phenotypes with different functions when the microenvironment changes which is called macrophage polarization. Macrophage polarization plays an important role in the immunoregulation of sepsis. The regulation of macrophage polarization is expected to be one of the new targets for the treatment of sepsis in the future. Therefore, we review the role of macrophage polarization and its underlying mechanisms in the immunoregulation of sepsis.

Key words: Sepsis, Macrophage polarization, Immune mechanism

Lingzhi Shen, Li Li, Jing Yan. The role of macrophage polarization in the immune mechanism of sepsis[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2019, 05(02): 185-189.

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URL: https://icu.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2096-1537.2019.02.018

https://icu.cma-cmc.com.cn/EN/Y2019/V05/I02/185

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