To explore the sedation effect and safety of Dexmedetomidine in patients with moderate craniocerebral trauma.

62 cases of craniocerebral trauma in our department from May 2015 to June 2018 were selected as the research objects. They were randomly divided into the observation group and the control group after obtaining informed consent from either the patient or an approved surrogate. Patients in observation group were treated with Dexmedetomidine and the other group with diazepam. We compared the sedation and adverse effect of the two groups before sedation and 10 min, 30 min, 60 min and 120 min after sedation.

After the sedation with Dexmedetomidine in the observation group, the pulse oxygen saturation (SpO₂) of patients was significantly higher than before, while 60 and 120 min after sedation SpO₂ of patients in the control group was remarkably higher than before (P<0.05). The respiratory rate (RR) of patient in the control group was significantly lower than that in the observation group 10 min and 30 min after sedation [(30.01±4.26) times/min vs. (25.13±3.94) times/min, (27.94±3.35) times/min vs. (23.09±4.26) times/min, all P<0.05]. The onset time (OT) and wakeup time (WT) of the observation group after drug withdrawal were significantly shorter than OT and WT of the control group [(68.34±7.01) s vs. (285.48±9.59) s, (6.53±1.76) min vs. (28.71±2.37) min, P<0.05]. The rate of adverse reaction was 12.90% in the observation group and lower than 41.93% in the control group (P<0.05).

The sedation effect and safety of Dexmedetomidine is better than that of diazepam for the patients with moderate craniocerebral trauma.