Sedation effect and safety of Dexmedetomidine in patients with moderate craniocerebral trauma

doi:10.3877/cma.j.issn.2096-1537.2019.03.007

Abstract

Abstract:

Objective

To explore the sedation effect and safety of Dexmedetomidine in patients with moderate craniocerebral trauma.

Methods

62 cases of craniocerebral trauma in our department from May 2015 to June 2018 were selected as the research objects. They were randomly divided into the observation group and the control group after obtaining informed consent from either the patient or an approved surrogate. Patients in observation group were treated with Dexmedetomidine and the other group with diazepam. We compared the sedation and adverse effect of the two groups before sedation and 10 min, 30 min, 60 min and 120 min after sedation.

Results

After the sedation with Dexmedetomidine in the observation group, the pulse oxygen saturation (SpO₂) of patients was significantly higher than before, while 60 and 120 min after sedation SpO₂ of patients in the control group was remarkably higher than before (P<0.05). The respiratory rate (RR) of patient in the control group was significantly lower than that in the observation group 10 min and 30 min after sedation [(30.01±4.26) times/min vs. (25.13±3.94) times/min, (27.94±3.35) times/min vs. (23.09±4.26) times/min, all P<0.05]. The onset time (OT) and wakeup time (WT) of the observation group after drug withdrawal were significantly shorter than OT and WT of the control group [(68.34±7.01) s vs. (285.48±9.59) s, (6.53±1.76) min vs. (28.71±2.37) min, P<0.05]. The rate of adverse reaction was 12.90% in the observation group and lower than 41.93% in the control group (P<0.05).

Conclusion

The sedation effect and safety of Dexmedetomidine is better than that of diazepam for the patients with moderate craniocerebral trauma.

Key words: Moderate craniocerebral trauma, Dexmedetomidine, Sedation

Haibo Kong, Yongcheng Jiao, Weiguang Zha. Sedation effect and safety of Dexmedetomidine in patients with moderate craniocerebral trauma[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2019, 05(03): 239-242.

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URL: https://icu.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2096-1537.2019.03.007

https://icu.cma-cmc.com.cn/EN/Y2019/V05/I03/239

Figures/Tables 2

References 11

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组别		RASS（分）	SpO₂（%）	HR（次/min）	RR（次/min）
观察组（31例）		?	?	?	?
?	镇静前	1.80±0.39	90.21±2.58	105.62±10.78	32.45±5.03
?	镇静后10 min	1.02±0.43	94.82±4.14^a	89.33±14.25	30.01±4.26^b
?	镇静后30 min	0.67±0.36	96.23±3.87^a	80.46±10.24	27.94±3.35^b
?	镇静后60 min	-1.59±0.15	96.81±3.54^a	71.92±12.06	23.47±5.04
?	镇静后120 min	-1.32±0.37	96.39±2.91^a	69.48±10.31	22.81±4.35
对照组（31例）		?	?	?	?
?	镇静前	2.20±0.64	92.11±3.87	97.24±11.94	33.02±4.46
?	镇静后10 min	0.50±0.34	93.56±4.26	88.43±10.11	25.13±3.94
?	镇静后30 min	-1.07±0.22	93.81±3.14	80.74±10.38	23.09±4.26
?	镇静后60 min	-2.14±0.86	96.01±2.14^a	74.45±10.62	21.86±5.04
?	镇静后120 min	-1.96±0.27	94.89±4.03^a	78.31±9.47	22.17±5.28

组别		RASS（分）	SpO₂（%）	HR（次/min）	RR（次/min）
观察组（31例）		?	?	?	?
?	镇静前	1.80±0.39	90.21±2.58	105.62±10.78	32.45±5.03
?	镇静后10 min	1.02±0.43	94.82±4.14^a	89.33±14.25	30.01±4.26^b
?	镇静后30 min	0.67±0.36	96.23±3.87^a	80.46±10.24	27.94±3.35^b
?	镇静后60 min	-1.59±0.15	96.81±3.54^a	71.92±12.06	23.47±5.04
?	镇静后120 min	-1.32±0.37	96.39±2.91^a	69.48±10.31	22.81±4.35
对照组（31例）		?	?	?	?
?	镇静前	2.20±0.64	92.11±3.87	97.24±11.94	33.02±4.46
?	镇静后10 min	0.50±0.34	93.56±4.26	88.43±10.11	25.13±3.94
?	镇静后30 min	-1.07±0.22	93.81±3.14	80.74±10.38	23.09±4.26
?	镇静后60 min	-2.14±0.86	96.01±2.14^a	74.45±10.62	21.86±5.04
?	镇静后120 min	-1.96±0.27	94.89±4.03^a	78.31±9.47	22.17±5.28

组别	例数	呼吸抑制	心动过缓	低血压	总发生［例（%）］
观察组	31	0	3	1	4（12.90）^a
对照组	31	7	2	4	13（41.93）

组别	例数	呼吸抑制	心动过缓	低血压	总发生［例（%）］
观察组	31	0	3	1	4（12.90）^a
对照组	31	7	2	4	13（41.93）

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