Acute gastrointestinal injury and cardiovascular disease

doi:10.3877/cma.j.issn.2096-1537.2020.02.007

Abstract

Abstract:

The gastrointestinal tract is the central organ of stress, and it is the initially involved organ of the multiple organ dysfunction syndrome. When acute gastrointestinal injury occurs, the gut mucosal barrier is damaged and the intestinal flora is also altered due to the change of gut microenvironment, which together leads to bacterial translocation and endotoxemia, and thus induces and exacerbates systemic inflammatory response syndrome, ultimately resulting in multiple organ dysfunction, including the cardiovascular system. This article reviews the progress in the understanding of the relationship between acute gastrointestinal injury and cardiovascular disease.

Key words: Acute gastrointestinal injury, Heart failure, Acute coronary syndrome

Lidi Zhang, Dechang Chen. Acute gastrointestinal injury and cardiovascular disease[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2020, 06(02): 143-145.

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URL: https://icu.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2096-1537.2020.02.007

https://icu.cma-cmc.com.cn/EN/Y2020/V06/I02/143

References 27

1	Mittal R, Coopersmith CM. Redefining the gut as the motor of critical illness[J]. Trends Mol Med, 2014, 20(4): 214-223.
2	Klingensmith NJ, Coopersmith CM. The gut as the motor of multiple organ dysfunction in critical illness[J]. Crit Care Clin, 2016, 32(2): 203-212.
3	Cabrera-Perez J, Badovinac VP, Griffith TS. Enteric immunity, the gut microbiome, and sepsis: Rethinking the germ theory of disease[J]. Exp Biol Med, 2017, 242(2): 127-139.
4	Shimizu K, Ogura H, Hamasaki T, et al. Altered gut flora are associated with septic complications and death in critically ill patients with systemic inflammatory response syndrome[J]. Dig Dis Sci, 2011, 56(4): 1171-1177.
5	Reintam Blaser A, Poeze M, Malbrain ML, et al. Gastrointestinal symptoms during the first week of intensive care are associated with poor outcome: a prospective multicentre study[J]. Intensive Care Med, 2013, 39(5): 899-909.
6	Vivier E, Metton O, Piriou V, et al. Effects of increased intra-abdominal pressure on central circulation[J]. Br J Anaesth, 2006, 96(6): 701-707.
7	Mahjoub Y, Plantefeve G. Cardiac ultrasound and abdominal compartment syndrome[J]. Acta Clin Belg, 2007, 62 (Suppl 1): 183-189.
8	Pasini E, Aquilani R, Testa C, et al. Pathogenic Gut Flora in Patients with Chronic Heart Failure[J]. JACC Heart Fail, 2016, 4(3): 220-227.
9	Kitai T, Kirsop J, Tang WH. Exploring the Microbiome in Heart Failure[J]. Curr Heart Fail Rep, 2016, 13(2): 103-109.
10	Sandek A, Bauditz J, Swidsinski A, et al. Altered intestinal function in patients with chronic heart failure[J]. J Am Coll Cardiol, 2007, 50(16): 1561-1569.
11	Cannon JA, McMurray JJ. Gut feelings about heart failure[J]. J Am Coll Cardiol, 2014, 64(18): 1915-1916.
12	Chrysohoou C, Pitsavos C, Barbetseas J, et al. Chronic systemic inflammation accompanies impaired ventricular diastolic function, detected by Doppler imaging, in patients with newly diagnosed systolic heart failure (Hellenic Heart Failure Study)[J]. Heart Vessels, 2009, 24(1): 22-26.
13	Valgimigli M, Ceconi C, Malagutti P, et al. Tumor necrosis factor-alpha receptor 1 is a major predictor of mortality and new-onset heart failure in patients with acute myocardial infarction: the Cytokine-Activation and Long-Term Prognosis in Myocardial Infarction (C-ALPHA) study[J]. Circulation, 2005, 111(7): 863-870.
14	Ueland T, Gullestad L, Nymo SH, et al. Inflammatory cytokines as biomarkers in heart failure[J]. Clin Chim Acta, 2015, 443: 71-77.
15	Kalogeropoulos AP, Georgiopoulou VV, Butler J. From risk factors to structural heart disease: the role of inflammation[J]. Heart Fail Clin, 2012, 8(1): 113-123.
16	Kitai T, Tang WHW. Gut microbiota in cardiovascular disease and heart failure[J]. Clin Sci (Lond), 2018, 132(1): 85-91.
17	Sandek A, Swidsinski A, Schroedl W, et al. Intestinal blood flow in patients with chronic heart failure: a link with bacterial growth, gastrointestinal symptoms, and cachexia[J]. J Am Coll Cardiol, 2014, 64(11): 1092-1102.
18	Tang WH, Wang Z, Fan Y, et al. Prognostic value of elevated levels of intestinal microbe-generated metabolite trimethylamine-N-oxide in patients with heart failure: refining the gut hypothesis[J]. J Am Coll Cardiol, 2014, 64(18): 1908-1914.
19	Tang WH, Hazen SL. The contributory role of gut microbiota in cardiovascular disease[J]. J Clin Invest, 2014, 124(10): 4204-4211.
20	Janeiro MH, Ramírez MJ, Milagro FI, et al. Implication of Trimethylamine N-Oxide (TMAO) in Disease: Potential Biomarker or New Therapeutic Target[J]. Nutrients, 2018, 10(10). pii: E1398.
21	Koeth RA, Wang Z, Levison BS, et al. Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis[J]. Nat Med, 2013, 19(5): 576-585.
22	Spector R. New Insight into the Dietary Cause of Atherosclerosis: Implications for Pharmacology[J]. J Pharmacol Exp Ther, 2016, 358(1): 103-108.
23	Chen ML, Zhu XH, Ran L, et al. Trimethylamine-N-Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3-SOD2-mtROS Signaling Pathway[J]. J Am Heart Assoc, 2017, 6(9): pii: e006347.
24	Sun G, Yin Z, Liu N, et al. Gut microbial metabolite TMAO contributes to renal dysfunction in a mouse model of diet-induced obesity[J]. Biochem Biophys Res Commun, 2017, 493(2): 964-970.
25	Li T, Gua C, Wu B, et al. Increased circulating trimethylamine N-oxide contributes to endothelial dysfunction in a rat model of chronic kidney disease[J]. Biochem Biophys Res Commun, 2018, 495(2): 2071-2077.
26	Curtiss LK, Tobias PS. Emerging role of Toll-like receptors in atherosclerosis[J]. J Lipid Res, 2009, 50 (Suppl): S340-S345.
27	Zhu W, Gregory JC, Org E, et al. Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk[J]. Cell, 2016, 165(1): 111-124.

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