Application of Shenfu injection in critically ill patients

doi:10.3877/cma.j.issn.2096-1537.2020.028

Abstract

Abstract:

The Shenfu injection (SFI) is the integration of Chinese traditional medicine and modern medicine. Recently, with the continuous exploration of its mechanism of pharmaceutical activity and the gradual deepening of clinical research, the application of SFI has been expanding. Especially in the treatment of critically ill patients, its effectiveness and safety has been constantly affirmed, and has attracted increasing attention of scholars. This article reviewed the mechanism of SFI and its application in critically ill patients, especially those with shock and cardiopulmonary resuscitation, in order to promote further basic medicine and clinical research in the future.

Key words: Shenfu, Critical care, Shock, Cardiopulmonary resuscitation

Xiang Si, Xiangdong Guan. Application of Shenfu injection in critically ill patients[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2020, 06(01): 92-95.

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URL: https://icu.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2096-1537.2020.028

https://icu.cma-cmc.com.cn/EN/Y2020/V06/I01/92

References 33

1	Yang H, Liu L, Gao W, et al. Direct and comprehensive analysis of ginsenosides and diterpene alkaloids in Shenfu injection by combinatory liquid chromatography-mass pectrometric techniques [J]. J Pharm Biom Anal, 2014, 92: 13-21.
2	Xiao Y, Ma ZC, Wang YG，et al. Cardioprotection of Shenfu preparata on cardiac myocytes through cytochrome P450 2J3 [J]. J Integr Med, 2013, 11(5): 327-336.
3	Ni J, Shi Y, Li L, et al. Cardioprotection against heart failure by Shenfu injection via TGF-β/Smads signaling pathway [J]. Evid Based Complement Alternat Med, 2017, 2017: 7083016.
4	Ji XF, Ji HB, Sang DY, et al. Shen-Fu injection reduces impaired myocardial β-adrenergic receptor signaling after cardiopulmonary resuscitation [J]. Chin Med J (Engl), 2013, 126(4): 697-702.
5	Gu W, Li C, Yin W, et al. Shen-fu injection reduces postresuscitation myocardial dysfunction in a porcine model of cardiac arrest by modulating apoptosis [J]. Shock, 2012, 38(3): 301-306.
6	Wu J, Li C, Yuan W. Effects of Shenfu injection on macrocirculation and microcirculation during cardiopulmonary resuscitation [J]. J Ethnopharmacol, 2016, 180: 97-103.
7	Wu Y, Xia ZY, Meng QT, et al. Shen-Fu injection preconditioning inhibits myocardial ischemia-reperfusion injury in diabetic rats: activation of eNOS via the PI3K/Akt pathway [J]. J Biomed Biotechnol, 2011, 2011: 384627.
8	Ji XF, Yang L, Zhang MY, et al. Shen-fuinjection attenuates postresuscitation myocardial dysfunction in a porcine model of cardiac arrest [J]. Shock, 2011, 35(5): 530-536.
9	Zhang Q, Li CS, Wang S, et al. Effects of Chinese medicine shen-fu injection on the expression of inflammatory cytokines and complements during post-resuscitation immune dysfunction in aporcine model [J]. Chin J Integrat Med, 2016, 22(2): 101-109.
10	Jin YY, Gao H, Zhang XY, et al. Shenfu injection inhibits inflammation in patients with acute myocardial infarction complicated by cardiac shock [J]. Chin J Integr Med, 2017, 23(3): 170-175.
11	Cao J, Zheng CD, Zhang GX, et al. Protective effect of Shenfu injection on myocardial mitochondria injured by ischemia-reperfusion in rabbits [J]. Chin Med J (Engl), 2005, 118(6): 505-507.
12	Zheng SY, Sun J, Zhao X, et al. Protective effect of Shenfu on myocardial ischemia-reperfusion injury in rats [J]. Am J Chin Med, 2004, 32(2): 209-209.
13	Singer M, Deutsehman CS, Seymour CW，et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) [J]. JAMA, 2016, 315(8): 801-810.
14	Xing X, Jiang R, Wang L, et al. Shenfu injection alleviates intestine epithelial damage in septic rats [J]. Am J Emerg Med, 2015, 33(11): 1665-1670.
15	Wang J, Qiao LF, Yang GT. Role of Shenfu injection in rats with systemic inflammatory response syndrome [J]. Chin J Integr Med, 2008, 14(1): 51-55.
16	Zhang N, Liu J, Qiu Z, et al. Shenfu injection for improving cellular immunity and clinical outcome in patients with sepsis or septic shock [J]. Am J Emerg Med, 2017, 35(1): 1-6.
17	Li MQ, Pan CG, Wang XM, et al. Effect of the shenfu injection combined with early goal-directed therapy on organ functions and outcomes of septic shock patients [J]. Cell Biochem Biophys, 2015, 72(3): 807-812.
18	Mou Z, Lv Z, Li Y, et al. Clinical effect of shenfu injection in patients with septic shock: a meta-analysis and systematic review [J]. Evid Based Complement Alternat Med, 2015, 2015: 863149.
19	Li Yi, Zhang XC, Lin PH, et al. Effects of Shenfu injection in the treatment of septic shock patients: a multicenter, controlled, randomized, open-label trial [J]. Evid Based Complement Alternat Med, 2016, 2016: 2565169.
20	中华医学会重症医学分会. 中国严重脓毒症/脓毒性休克治疗指南(2014) [J]. 中华内科杂志, 2015, 54(6): 557-581.
21	中国医师协会急诊医师分会，中国研究型医院学会休克与脓毒症专业委员会.中国脓毒症/脓毒性休克急诊治疗指南(2018) [J]. 中国急救医学, 2018, 38(9): 741-756.
22	邓永诚，董丽军. 参附注射液对心力衰竭患者心功能及血浆脑钠肽水平的影响 [J/CD]. 中华危重症医学杂志(电子版), 2010, 3(5): 17-19.
23	Song WT, Cheng FF, Xu L, et al. Chinese medicine shenfu injection for heart failure: a systematic review and meta-analysis [J]. Evid Based Complement Alternat Med, 2012, 2012: 713149.
24	叶淑. 参附注射液治疗急性心力衰竭疗效观察 [J]. 现代中西医结合杂志, 2016, 25(13): 1449-1451.
25	毕晓锋，刘国斌. 参附注射液治疗心源性休克的疗效观察 [J]. 实用临床医学, 2005, 6(9): 32-34.
26	张熹煜，钟敏莹. 参附注射液联合主动脉内球囊反搏术治疗心源性休克临床观察 [J]. 新中医, 2010, 42(9): 18-19.
27	Ji XF, Yang L, Zhang MY, et al. Shen-fu injection attenuates postresuscitation myocardial dysfunction in a porcine model of cardiac arrest [J]. Shock, 2011, 35(5): 530-536.
28	Zhang MY, Ji XF, Wang S, et al. Shen-fu injection attenuates postresuscitation lung injury in a porcine model of cardiac arrest [J]. Resuscitation, 2012, 83(9): 1152-1158.
29	Hou X, Li C, Gu W, et al. Effect of Shenfu on inflammatory cytokine release and brain edema after prolonged cardiac arrest in the swine [J]. Am J Emerg Med, 2013, 31(8): 1159-1164.
30	Zhang Q, Li C, Shao F, et al. Efficacy and safety of combination therapy of shenfu injection and postresuscitation bundle in patients with return of spontaneous circulation after in-hospital cardiac arrest: a randomized, assessor-blinded, controlled trial [J]. Crit Care Med, 2017, 45(10): 1587-1595.
31	Xia ZY, Liu X, Zhan LY, et al. Ginsenosides compound (shen-fu) attenuates gastrointestinal injury and inhibits inflammatory response after cardiopulmonary bypass in patients with congenital heart disease [J]. J Thorac Cardiovasc Surg, 2005, 130(2): 258-264.
32	Lv SJ, Lai DP, Wei X, et al. The protective effect of Shenfu injection against elderly severe pneumonia [J]. Eur J Trauma Emerg Surg, 2017, 43(5): 711-715.
33	Mo Y, Liu X, Qin X, et al. Shenfu injection for intradialytic hypotension: a systematic review and meta-analysis [J]. Evid Based Complement Alternat Med, 2014, 2014: 279853.

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