Spreading depolarization in patients with traumatic brain injury

doi:10.3877/cma.j.issn.2096-1537.2020.03.009

Abstract

Abstract:

Objective

To analyze the incidence of spreading depolarization in patients with acute brain injury.

Methods

Quantitative electroencephalogram (EEG) data of patients with acute brain injury admitted to the intensive care unit of Xiangya Hospital of Central South University were retrospectively reviewed to analyze the incidence of spreading depolarization.

Results

Among the 37 patients with acute brain injury included, 14 had spreading depolarization with an average duration of 8.91±3.03 minutes. Amplitude integrated electroencephalogram (aEEG) decreased by 66.78%±9.31% on average from baseline.

Conclusion

Spreading depolarization has a high incidence in patients with acute brain injury, and it can be monitored by quantitative EEG, which may be an indicator of multimodal brain function monitoring in future.

Key words: Craniocerebral trauma, Electroencephalography, Spreading depolarization

Chunguang Zhao, Xingshu Ren, Meilin Ai, Li Huang, Qi Liu, Qianyi Peng, Yuhang Ai, Lina Zhang. Spreading depolarization in patients with traumatic brain injury[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2020, 06(03): 286-291.

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URL: https://icu.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2096-1537.2020.03.009

https://icu.cma-cmc.com.cn/EN/Y2020/V06/I03/286

Figures/Tables 4

References 22

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序号	性别	年龄（岁）	原发病	GCS评分	播散性去极化次数	aEEG平均下降幅度（%）	aEEG平均下降时间（min）
1	男	80	脑外伤	6	7	75.89	12.4
2	女	76	腔隙性脑梗死	4	5	74.28	10.4
3	女	60	脑外伤	4	2	75.05	11.5
4	男	55	自发性脑出血	5	2	50.80	10.0
5	女	54	自发性脑出血	3	3	53.60	11.0
6	男	72	心肺复苏术后	5	1	58.60	12.0
7	男	53	脑外伤	6	5	63.56	8.2
8	女	82	自发性脑出血	4	4	70.88	8.2
9	女	54	自发性脑出血	3	1	65.70	10.0
10	男	60	脑外伤	6	1	52.90	2.0
11	女	53	自发性脑出血	3	2	64.96	6.5
12	女	55	自发性脑出血	6	3	73.17	4.7
13	男	46	自发性脑出血	3	1	75.93	2.0
14	男	57	心肺复苏术后	3	3	79.51	4.3
15	女	78	自发性脑出血	6	-	-	-
16	女	40	心肺复苏术后	5	-	-	-
17	女	65	自发性脑出血	5	-	-	-
18	男	18	脑外伤	6	-	-	-
19	男	56	自发性脑出血	11	-	-	-
20	男	16	胶质瘤	5	-	-	-
21	男	54	心肺复苏术后	4	-	-	-
22	男	69	心肺复苏术后	3	-	-	-
23	男	63	自发性脑出血	6	-	-	-
24	女	31	自发性脑出血	3	-	-	-
25	女	68	自发性脑出血	5	-	-	-
26	女	44	破伤风	6	-	-	-
27	男	86	脑外伤	13	-	-	-
28	女	60	心肺复苏术后	3	-	-	-
29	男	50	脑外伤	3	-	-	-
30	女	46	自发性脑出血	3	-	-	-
31	女	25	癫痫	13	-	-	-
32	男	65	垂体瘤术后	4	-	-	-
33	男	63	自发性脑出血	6	-	-	-
34	男	49	脑梗塞	4	-	-	-
35	女	82	自发性脑出血	3	-	-	-
36	男	52	自发性脑出血	3	-	-	-
37	女	69	自发性脑出血	3	-	-	-

序号	性别	年龄（岁）	原发病	GCS评分	播散性去极化次数	aEEG平均下降幅度（%）	aEEG平均下降时间（min）
1	男	80	脑外伤	6	7	75.89	12.4
2	女	76	腔隙性脑梗死	4	5	74.28	10.4
3	女	60	脑外伤	4	2	75.05	11.5
4	男	55	自发性脑出血	5	2	50.80	10.0
5	女	54	自发性脑出血	3	3	53.60	11.0
6	男	72	心肺复苏术后	5	1	58.60	12.0
7	男	53	脑外伤	6	5	63.56	8.2
8	女	82	自发性脑出血	4	4	70.88	8.2
9	女	54	自发性脑出血	3	1	65.70	10.0
10	男	60	脑外伤	6	1	52.90	2.0
11	女	53	自发性脑出血	3	2	64.96	6.5
12	女	55	自发性脑出血	6	3	73.17	4.7
13	男	46	自发性脑出血	3	1	75.93	2.0
14	男	57	心肺复苏术后	3	3	79.51	4.3
15	女	78	自发性脑出血	6	-	-	-
16	女	40	心肺复苏术后	5	-	-	-
17	女	65	自发性脑出血	5	-	-	-
18	男	18	脑外伤	6	-	-	-
19	男	56	自发性脑出血	11	-	-	-
20	男	16	胶质瘤	5	-	-	-
21	男	54	心肺复苏术后	4	-	-	-
22	男	69	心肺复苏术后	3	-	-	-
23	男	63	自发性脑出血	6	-	-	-
24	女	31	自发性脑出血	3	-	-	-
25	女	68	自发性脑出血	5	-	-	-
26	女	44	破伤风	6	-	-	-
27	男	86	脑外伤	13	-	-	-
28	女	60	心肺复苏术后	3	-	-	-
29	男	50	脑外伤	3	-	-	-
30	女	46	自发性脑出血	3	-	-	-
31	女	25	癫痫	13	-	-	-
32	男	65	垂体瘤术后	4	-	-	-
33	男	63	自发性脑出血	6	-	-	-
34	男	49	脑梗塞	4	-	-	-
35	女	82	自发性脑出血	3	-	-	-
36	男	52	自发性脑出血	3	-	-	-
37	女	69	自发性脑出血	3	-	-	-

组别	例数	男/女（例）	年龄（岁）	GCS评分
去极化患者	14	7/7	61.2±11.0	4.3±1.2
未去极化患者	23	12/11	54.3±18.6	5.4±3.0
统计值		χ²=0.016	t=1.345	t=1.337
P值		0.898	0.114	0.177

组别	例数	男/女（例）	年龄（岁）	GCS评分
去极化患者	14	7/7	61.2±11.0	4.3±1.2
未去极化患者	23	12/11	54.3±18.6	5.4±3.0
统计值		χ²=0.016	t=1.345	t=1.337
P值		0.898	0.114	0.177

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