Duration of viral shedding in a family clustered COVID-19 infection: case report

doi:10.3877/cma.j.issn.2096-1537.2021.01.017

Abstract

Abstract:

The coronavirus disease 2019(COVID-19) epidemic swept more than a hundred countries and regions and has been officially characterized as a global pandemic by the World Health Organization. Since the occurrence of the disease, many articles have successively reported epidemiological and clinical characteristics of COVID-19 patients, but there are few reports on analysis of risk factors for mortality, clinical course and duration of viral shedding. In this paper, a family clustered outbreak was reported, and it was found that the duration of viral shedding in COVID-19 patients was not fully consistent with the severity of the disease. Specific therapeutics are still lacking for 2019 novel coronavirus pneumonia and research into it has not been discontinued.

Key words: COVID-19, Nucleic acid testing, Family cluster

Fuxing Li, Zhiyong Sheng. Duration of viral shedding in a family clustered COVID-19 infection: case report[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2021, 07(01): 93-96.

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https://icu.cma-cmc.com.cn/EN/Y2021/V07/I01/93

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References 13

1	Who Director-General Dr Tedros Adhanom Ghebreyesus. https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19---11-march-2020 [EB/OL]. 2020.3.11.
2	Gorbalenya AE, Baker SC, Baric RS, et al. Severe acute respiratory syndrome-related coronavirus: The species and its viruses-a statement of the Coronavirus Study Group [J]. Nat Microbiol, 2020.02.07.
3	Zhu N, Zhang D, Wang W, et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019 [J]. N Engl J Med, 2020, 382(8): 727-773.
4	Perlman S. Another decade, another coronavirus [J]. N Engl J Med, 2020, 382(8): 760-762.
5	Tang X, Wu C, Li X, et al. On the origin and continuing evolution of SARS-CoV-2 [J]. Nat Sci Rev, 2020, 7(6): 1012–1023.
6	Li Q, Guan X, Wu P, et al. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia [J]. N Engl J Med, 2020, 382(13): 1199-1207.
7	Lu R, Zhao X, Li J, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding [J]. Lancet, 2020, 395(10224): 565-574.
8	Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China [J]. Lancet, 2020, 395(10233): 497-506.
9	Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study [J]. Lancet, 2020, 395(10223): 507-513.
10	Wang D, Hu B, Hu C, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China [J]. JAMA, 2020, 323(11): 1061-1069.
11	Bajema KL, Oster AM, McGovern OL, al et; 2019-nCoV Persons Under Investigation Team; 2019-CoV Persons Under Investigation Team. Persons Evaluated for 2019 Novel Coronavirus - United States, January 2020 [J]. MMWR Morb Mortal Wkly Rep, 2020, 69(6): 166-170.
12	国家卫生健康委员会. 新型冠状病毒肺炎诊疗方案(试行第七版) [EB/OL]. 2020年3月4日. URL
13	Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study [J]. Lancet, 2020, 395(10229): 1054-1062.

检测指标	病例1	病例2	病例3
血常规	正常	嗜酸性细胞0.09%（0.4%~8.0%）嗜酸性粒细胞绝对值计数0（0.02×10⁹~0.52×10⁹）	白细胞9.52×10⁹/L（3.5×10⁹~9.5×10⁹）淋巴细胞18.9%（20%~50%）嗜酸性细胞0.09%（0.4%~8.0%）中性粒细胞6.97×10⁹/L（1.8×10⁹~6.3×10⁹）单核细胞0.69×10⁹/L（0.1×10⁹~0.6×10⁹）嗜酸性细胞0.01×10⁹/L（0.02×10⁹~0.52×10⁹）
生化	正常	空腹血糖6.33 mmol/L（3.9~6.1）	尿酸461.0 μmol/L（208~428）尿素14.30 mmol/L（2.9~8.2）胱抑素C 3.27 mg/L（＜1.0）肌酐265.0 μmol/L（44~133.0）空腹血糖14.19 mmol/L（3.9~6.1） γ-谷氨酰转移酶69 U/L（11~50）
心肌酶	正常	正常	肌酸激酶327 U/L（38~174）乳酸脱氢酶290 U/L（109~245）
凝血功能	正常	纤维蛋白原5.12 g/L（2~4）	纤维蛋白原6.49 g/L（2~4） D-二聚体1.02 mg/L（＜0.5）
降钙素原	正常	正常	正常
高敏C反应蛋白	正常	正常	13.14 mg/L（＜4）
T淋巴细胞亚群	正常	CD4⁺T淋巴细胞55.02%（25.34%~51.37%）	正常
细胞因子6项	IL-6：7.41 pg/ml（0.10~2.90） IL-4：6.13 pg/ml（0.10~3.20） IL-2：5.84 pg/ml（0.10~4.10） IL-10正常 TNF-α正常 IFN-γ正常	IL-6：6.81 pg/ml（0.10~2.90） IL-4：5.41 pg/ml（0.10~3.20） IL-2：6.32 pg/ml（0.10~4.10） IL-10：8.67 pg/ml（0.10~5.00） TNF-α正常 IFN-γ正常	IL-6：21.32 pg/ml（0.10~2.90） IL-4：5.33 pg/ml（0.10~3.20） IL-2：6.61 pg/ml（0.10~4.10） IL-10：6.81 pg/ml（0.10~5.00） TNF-α正常 IFN-γ正常

检测指标	病例1	病例2	病例3
血常规	正常	嗜酸性细胞0.09%（0.4%~8.0%）嗜酸性粒细胞绝对值计数0（0.02×10⁹~0.52×10⁹）	白细胞9.52×10⁹/L（3.5×10⁹~9.5×10⁹）淋巴细胞18.9%（20%~50%）嗜酸性细胞0.09%（0.4%~8.0%）中性粒细胞6.97×10⁹/L（1.8×10⁹~6.3×10⁹）单核细胞0.69×10⁹/L（0.1×10⁹~0.6×10⁹）嗜酸性细胞0.01×10⁹/L（0.02×10⁹~0.52×10⁹）
生化	正常	空腹血糖6.33 mmol/L（3.9~6.1）	尿酸461.0 μmol/L（208~428）尿素14.30 mmol/L（2.9~8.2）胱抑素C 3.27 mg/L（＜1.0）肌酐265.0 μmol/L（44~133.0）空腹血糖14.19 mmol/L（3.9~6.1） γ-谷氨酰转移酶69 U/L（11~50）
心肌酶	正常	正常	肌酸激酶327 U/L（38~174）乳酸脱氢酶290 U/L（109~245）
凝血功能	正常	纤维蛋白原5.12 g/L（2~4）	纤维蛋白原6.49 g/L（2~4） D-二聚体1.02 mg/L（＜0.5）
降钙素原	正常	正常	正常
高敏C反应蛋白	正常	正常	13.14 mg/L（＜4）
T淋巴细胞亚群	正常	CD4⁺T淋巴细胞55.02%（25.34%~51.37%）	正常
细胞因子6项	IL-6：7.41 pg/ml（0.10~2.90） IL-4：6.13 pg/ml（0.10~3.20） IL-2：5.84 pg/ml（0.10~4.10） IL-10正常 TNF-α正常 IFN-γ正常	IL-6：6.81 pg/ml（0.10~2.90） IL-4：5.41 pg/ml（0.10~3.20） IL-2：6.32 pg/ml（0.10~4.10） IL-10：8.67 pg/ml（0.10~5.00） TNF-α正常 IFN-γ正常	IL-6：21.32 pg/ml（0.10~2.90） IL-4：5.33 pg/ml（0.10~3.20） IL-2：6.61 pg/ml（0.10~4.10） IL-10：6.81 pg/ml（0.10~5.00） TNF-α正常 IFN-γ正常

病例	入院7 d	入院14 d	入院16 d	入院18 d	入院20 d	入院24 d
1	2019nCov-N阳性，nCovORFlab阳性	阴性	阴性	出院	出院	出院
2	2019nCov-N阳性，nCovORFlab阳性	2019nCov-N阳性，nCovORFlab阳性	未测	阴性	2019nCov-N阳性，nCovORFlab阴性	2019nCov-N阳性，nCovORFlab阴性
3	2019nCov-N阳性，nCovORFlab阳性	2019nCov-N阳性，nCovORFlab阳性	未测	阴性	阴性	阴性

病例	入院7 d	入院14 d	入院16 d	入院18 d	入院20 d	入院24 d
1	2019nCov-N阳性，nCovORFlab阳性	阴性	阴性	出院	出院	出院
2	2019nCov-N阳性，nCovORFlab阳性	2019nCov-N阳性，nCovORFlab阳性	未测	阴性	2019nCov-N阳性，nCovORFlab阴性	2019nCov-N阳性，nCovORFlab阴性
3	2019nCov-N阳性，nCovORFlab阳性	2019nCov-N阳性，nCovORFlab阳性	未测	阴性	阴性	阴性

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