Potential role of extracellular vesicles in acute respiratory distress syndrome

doi:10.3877/cma.j.issn.2096-1537.2021.02.015

Abstract

Abstract:

Acute respiratory distress syndrome (ARDS) is a life-threatening syndrome caused by pulmonary and extrapulmonary injury. The mortality remains high and the pathogenesis still needs to be further clarified. Recent studies have shown that imbalanced immune responses play an important role in the occurrence and development of ARDS. Extracellular vesicles (EVs) are small non-nucleated cell structures secreted by cells, which can target and transfer a variety of biological substances among various cell types, and play an important role in cell communication and material transfer. In recent years, research on EVs has provided new ideas for the pathogenesis and treatment of ARDS. We review the progress of potential biomarkers and therapeutic effects of EVs in ARDS, and proposes that EVs from different cell sources may be used as biomarkers for early recognition and new management target in ARDS in this manuscript.

Key words: Acute respiratory distress syndrome, Extracellular vesicles, Biomarkers

Haofei Wang, Yingzi Huang. Potential role of extracellular vesicles in acute respiratory distress syndrome[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2021, 07(02): 174-179.

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URL: https://icu.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2096-1537.2021.02.015

https://icu.cma-cmc.com.cn/EN/Y2021/V07/I02/174

References 38

1	Matthay M, Zemans R, Zimmerman G, et al. Acute respiratory distress syndrome [J]. Nat Rev Dis Primers, 2019, 5(1): 18.
2	Chiumello D, Brochard L, Marini J, et al. Respiratory support in patients with acute respiratory distress syndrome: an expert opinion [J]. Crit Care, 2017, 21(1): 240.
3	Bellani G, Laffey J, Pham T, et al. Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries [J]. JAMA, 2016, 315(8): 788-800.
4	Théry C, Witwer K, Aikawa E, et al. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines [J]. J Extracell Vesicles, 2018, 7(1): 1535750.
5	Shao H, Im H, Castro C, et al. New technologies for analysis of extracellular vesicles [J]. Chem Rev, 2018, 118(4): 1917-1950.
6	O'brien K, Breyne K, Ughetto S, et al. RNA delivery by extracellular vesicles in mammalian cells and its applications [J]. Nat Rev Mol Cell Biol, 2020, 21(10): 585-606.
7	Mathieu M, Martin-Jaular L, Lavieu G, et al. Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication [J]. Nat Cell Biol, 2019, 21(1): 9-17.
8	Cossetti C, Iraci N, Mercer T, et al. Extracellular vesicles from neural stem cells transfer IFN-γ via Ifngr1 to activate Stat1 signaling in target cells [J]. Mol Cell, 2014, 56(2): 193-204.
9	Gupta R, Radicioni G, Abdelwahab S, et al. Intercellular communication between airway epithelial cells is mediated by exosome-like vesicles [J]. Am J Respir Cell Mol Biol, 2019, 60(2): 209-220.
10	Matthay M, Zemans R. The acute respiratory distress syndrome: pathogenesis and treatment [J]. Annu Rev Pathol, 2011, 6: 147-163.
11	Buesing K, Densmore J, Kaul S, et al. Endothelial microparticles induce inflammation in acute lung injury [J]. J Surg Res, 2011, 166(1): 32-39.
12	Calfee C, Delucchi K, Sinha P, et al. Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial [J]. Lancet Respir Med, 2018, 6(9): 691-698.
13	Liu A, Park J, Zhang X, et al. Ex vivo therapeutic effects of hyaluronic acid in bacterial pneumonia in perfused human lungs [J]. Am J Respir Crit Care Med, 2019, 200(10): 1234-1245.
14	Soni S, Wilson M, O'dea K, et al. Alveolar macrophage-derived microvesicles mediate acute lung injury [J]. Thorax, 2016, 71(11): 1020-1029.
15	Ye C, Li H, Bao M, et al. Alveolar macrophage - derived exosomes modulate severity and outcome of acute lung injury [J]. Aging, 2020, 12(7): 6120-6128.
16	Mitra S, Exline M, Habyarimana F, et al. Microparticulate caspase 1 regulates gasdermin D and pulmonary vascular endothelial cell injury [J]. Am J Respir Cell Mol Biol, 2018, 59(1): 56-64.
17	Middleton E, Weyrich A, Zimmerman G. Platelets in pulmonary immune responses and inflammatory lung diseases [J]. Physiol Rev, 2016, 96(4): 1211-1259.
18	Brown G, Mcintyre T. Lipopolysaccharide signaling without a nucleus: kinase cascades stimulate platelet shedding of proinflammatory IL-1β-rich microparticles [J]. J Immunol, 2011, 186(9): 5489-5496.
19	Watanabe J, Marathe G, Neilsen P, et al. Endotoxins stimulate neutrophil adhesion followed by synthesis and release of platelet-activating factor in microparticles [J]. J Biol Chem, 2003, 278(35): 33161-33168.
20	Lee H, Zhang D, Laskin D, et al. Functional evidence of pulmonary extracellular vesicles in infectious and noninfectious lung inflammation [J]. J Immunol, 2018, 201(5): 1500-1509.
21	Kojima M, Gimenes-Junior J, Chan T, et al. Exosomes in postshock mesenteric lymph are key mediators of acute lung injury triggering the macrophage activation via Toll-like receptor 4 [J]. FASEB J, 2018, 32(1): 97-110.
22	Mcvey M, Tabuchi A, Kuebler W. Microparticles and acute lung injury [J]. Am J Physiol Lung Cell Mol Physiol, 2012, 303(5): L364-381.
23	Shaver C, Woods J, Clune J, et al. Circulating microparticle levels are reduced in patients with ARDS [J]. Crit Care, 2017, 21(1): 120.
24	Guervilly C, Lacroix R, Forel J, et al. High levels of circulating leukocyte microparticles are associated with better outcome in acute respiratory distress syndrome [J]. Crit Care, 2011, 15(1): R31.
25	Neudecker V, Brodsky KS, Clambey ET, et al. Neutrophil transfer of miR-223 to lung epithelial cells dampens acute lung injury in mice [J]. Sci Transl Med, 2017, 9(408): eaah5360.
26	Dalli J, Serhan C. Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators [J]. Blood, 2012, 120(15): e60-72.
27	Mohning M, Thomas S, Barthel L, et al. Phagocytosis of microparticles by alveolar macrophages during acute lung injury requires MerTK [J]. Am J Physiol Lung Cell Mol Physiol, 2018, 314(1): L69-L82.
28	Li Z, Scott M, Brzóska T, et al. Lung epithelial cell-derived IL-25 negatively regulates LPS-induced exosome release from macrophages [J]. Mil Med Res, 2018, 5(1): 24.
29	Morrison T, Jackson M, Cunningham E, et al. Mesenchymal stromal cells modulate macrophages in clinically relevant lung injury models by extracellular vesicle mitochondrial transfer [J]. Am J Respir Crit Care Med, 2017, 196(10): 1275-1286.
30	Song Y, Dou H, Li X, et al. Exosomal miR-146a contributes to the enhanced therapeutic efficacy of interleukin-1β-primed mesenchymal stem cells against sepsis [J]. Stem Cell, 2017, 35(5): 1208-1221.
31	Krasnodembskaya A, Samarani G, Song Y, et al. Human mesenchymal stem cells reduce mortality and bacteremia in gram-negative sepsis in mice in part by enhancing the phagocytic activity of blood monocytes [J]. Am J Physiol Lung Cell Mol Physiol, 2012, 302(10): L1003-1013.
32	Hao Q, Gudapati V, Monsel A, et al. Mesenchymal stem cell-derived extracellular vesicles decrease lung injury in mice [J]. J Immunol, 2019, 203(7): 1961-1972.
33	Tang X, Shi L, Monsel A, et al. Mesenchymal stem cell microvesicles attenuate acute lung injury in mice partly mediated by Ang-1 mRNA [J]. Stem cells, 2017, 35(7): 1849-1859.
34	Shah T, Qin S, Vashi M, et al. Alk5/Runx1 signaling mediated by extracellular vesicles promotes vascular repair in acute respiratory distress syndrome [J]. Clin Transl Med, 2018, 7(1): 19.
35	Khatri M, Richardson L, Meulia T. Mesenchymal stem cell-derived extracellular vesicles attenuate influenza virus-induced acute lung injury in a pig model [J]. Stem Cell Res Ther, 2018, 9(1): 17.
36	Islam M, Das S, Emin M, et al. Mitochondrial transfer from bone-marrow-derived stromal cells to pulmonary alveoli protects against acute lung injury [J]. Nat Med, 2012, 18(5): 759-765.
37	Lienau J, Müller-Redetzky H, Suttorp N, et al. New pathogenetic concepts and pharmacological studies on adjuvant therapy in severe pneumonia [J]. Pneumologie, 2016, 70(6): 372-378.
38	Lai C, Mardini O, Ericsson M, et al. Dynamic biodistribution of extracellular vesicles in vivo using a multimodal imaging reporter [J]. ACS Nano, 2014, 8(1): 483-494.

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