Research progress on the function of surfactant protein -D and its role in the common lung diseases

doi:10.3877/cma.j.issn.2096-1537.2022.02.013

Abstract

Abstract:

Lung surfactant protein D (SP-D) is a glycoprotein of the lectin family. In lungs it is synthesized and secreted mainly in the alveolar type Ⅱ epithelial cells and non-ciliated bronchiole epithelial cells, and are stored in secretory granules of Clara cells. SP-D is one of the surfactant binding proteins and is also a part of the pulmonary surfactant system. In addition to contributing to the homeostasis of surfactant pools in alveolar space, SP-D also exhibits functions of host defense and immunoregulation. This paper summarizes some relevant studies on SP-D in acute lung diseases in recent years, providing important theoretical basis for the potential treatment of many lung diseases, especially in inflammatory lung diseases.

Key words: Surfactant proteins D, Homeostasis of surfactant pools, Host defense, Immune regulation

Juanli Liu, Siqing Ma, Qiang Chen. Research progress on the function of surfactant protein -D and its role in the common lung diseases[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2022, 08(02): 167-172.

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