At the most critical and urgent time of Omicron outbreak in Shanghai, the second division of the Hunan′s third critical care team, which formed by the Second Xiangya Hospital of Central South University and Hunan Provincial People′s Hospital, took over designated ICU of Shuguang West Hospital, Shanghai University of Traditional Chinese Medicine. A total of 50 critically ill patients were treated successfully by the medical team with zero-infection among medical staff. Effective management of "intensive care unit without walls" can help early recognition and intervention of deteriorating patients, which resulted a mortality reduction. In a short time, we organized a standardized, professional, and sophisticated integrated critical care team to accomplish the medical treatment task with high quality. We explored some experience, including emphasizing political education, nosocomial infection control, close cooperation with local hospital and early recognition of critically ill patients. We discussed the construction and cooperation of the formed critical care team from multi-hospital and multi-discipline and the efficient operation, reflection, and exploration during special circumstance to provide help for for similar public health emergencies in the future.