Research progress of CXCL13 in central nervous system infection

doi:10.3877/cma.j.issn.2096-1537.2024.01.009

Abstract

Abstract:

Central nervous system infection (CNSI) is a general term for a group of diseases in which central nervous system is invaded by different pathogens, resulting in damage to the corresponding nerve tissue and clinical symptoms. Early diagnosis and timely and thorough treatment are key steps to reduce mortality and complications. However, the sensitivity and specificity of current diagnostic methods do not fully meet clinical needs. The chemokine CXC ligand 13 (CXCL13) is an important pillar of host immune response, which can maintain and promote inflammation, and is closely related to inflammatory diseases in central nervous system. Therefore, CXCL13 is considered a potential biomarker for diagnosis and treatment of CNSI. This article aims to explore the role of CXCL13 in CNSI and analyze its significance in diagnosing CNSI, assessing disease progression and efficacy.

Key words: CXC chemokine ligand 13, Central nervous system infection, Neurolympic disease, Forest encephalopathy, Neurosyphilis

Zhaolong Zhang, Hui Zheng, Danyang Zhao, Congyi Zhao, Zhiqi Liu, Youjia Zhang, Bingyu Qin. Research progress of CXCL13 in central nervous system infection[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2024, 10(01): 54-59.

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URL: https://icu.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2096-1537.2024.01.009

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