Advances in the study of Connexin 43 in lung diseases

doi:10.3877/cma.j.issn.2096-1537.2024.01.010

Abstract

Abstract:

Connexin 43 (Cx43), as the first discovered connexin, plays a vital role in intercellular junction and communication, and its expression in the lung has a great influence on the regulation of the air-blood barrier and permeability. Cx43 was proven to promote or inhibit various lung diseases, including acute lung injury/acute respiratory distress syndrome, asthma, pulmonary hypertension, lung cancer, COVID-19, and others. It depends on the mediating signal pathway and the interaction of different signal molecules. We aim to investigate the function of Cx43 in lung growth and development, as well as its involvement in injury repair and various lung disorders. Through an comprehensive understanding of the regulatory mechanism of Cx43 in these diseases, it is expected that new insights will be provided for the prevention, diagnosis, and treatment of lung diseases, and guide future research and clinical practice.

Key words: Cx43, Acute lung injury/Acute respiratory distress syndrome, Asthma, Lung cancer, Corona virus disease 2019

Haonan Li, Yupeng Zhang, Yan Fu, Jiwei Feng, Kai Liu, Wenkai Zhang. Advances in the study of Connexin 43 in lung diseases[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2024, 10(01): 60-65.

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URL: https://icu.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2096-1537.2024.01.010

https://icu.cma-cmc.com.cn/EN/Y2024/V10/I01/60

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