Research progress of myeloid derived suppressor cells in sepsis

doi:10.3877/cma.j.issn.2096-1537.2024.03.011

Abstract

Abstract:

Sepsis is the main cause of ICU admission. Sepsis originates from an infection and progresses due to host desregulated immune response, ultimately leading to deterioration in tissues and organs. The pathogenesis of sepsis is complicate, with multiple mechanisms involved in its pathological and physiological processes. The immune state of the body is significantly disrupted. Thanks to the ongoing advancements in medical technology and the increasing knowledge of sepsis by ICU physicians, sepsis patients can typically endure the initial inflammatory response. However, in the later stages, they are susceptible to secondary infections due to immune suppression, which still carries a significant risk of mortality. At present, the research on sepsis mainly focuses on immunosuppression and immunomodulatory strategies. We review the nomenclature, origin, and research progress of myeloid suppressor cells (MDSCs) in sepsis in this manuscript. It also presents the theoretical foundation for future treatments of sepsis-related immune dysfunctions.

Key words: Sepsis, Medullary suppressor cells, Differentiation, Plateau area

Juanli Liu, Siqing Ma, Wurentana. Research progress of myeloid derived suppressor cells in sepsis[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2024, 10(03): 271-278.

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URL: https://icu.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2096-1537.2024.03.011

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