Research progress in mtDNA in lung injury of ARDS patients

doi:10.3877/cma.j.issn.2096-1537.2025.02.019

Abstract

Abstract:

Acute respiratory distress syndrome （ARDS） is a common respiratory critical syndrome and one of the main causes of death in critically ill patients.It has been a hot and difficult point in respiratory and critical care medicine for many years.More and more studies have found that mitochondrial DNA （mtDNA）levels are associated with the development of ARDS.Plasma mtDNA levels are expected to be biomarkers for clinical diagnosis and evaluation of ARDS lung injury severity.In this review，we elaborate on the release and production of mtDNA and the underlying mechanisms leading to ARDS injury，prospecting for new therapies for ARDS targeting mtDNA.

Key words: Mitochondrial DNA, Acute respiratory distress syndrome, Lung injury

Lili Huang, Yi Yang, Haibo Qiu. Research progress in mtDNA in lung injury of ARDS patients[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2025, 11(02): 204-209.

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URL: https://icu.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2096-1537.2025.02.019

https://icu.cma-cmc.com.cn/EN/Y2025/V11/I02/204

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