Research progress of host response recognition of sepsis-causing pathogens

doi:10.3877/cma.j.issn.2096-1537.2026.02.017

Abstract

Abstract:

Sepsis is a life-threatening clinical syndrome characterized by dysregulated host responses to infection, resulting in severe organ dysfunction. Although early and appropriate antimicrobial therapy remains the cornerstone of sepsis management, conventional diagnostic methods often fail to meet the clinical requirements for accuracy and timeliness in pathogen identification. Recent breakthroughs in pathogen identification through differential host immune responses offer a promising framework for a new diagnostic and therapeutic paradigm. This review summarizes progress in host-response-oriented pathogen identification, aiming to provide clinicians with innovative strategies for early, precise formulation of anti-infective regimens.

Key words: Sepsis, Host response, Pathogenic pathogens, Diagnosis

Xiang Yang, Lanqi Guo, Jianfeng Xie, Haibo Qiu. Research progress of host response recognition of sepsis-causing pathogens[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2026, 12(02): 196-201.

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https://icu.cma-cmc.com.cn/EN/Y2026/V12/I02/196

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