Acute kidney injury: pathophysiology and treatment

doi:10.3877/cma.j.jssn.2096-1537.2015.01.011

Abstract

Abstract:

Acute kidney injury (AKI) is a common clinical syndrome and mainly manifested by the rapid decline of renal function and the accumulation of metabolic waste. The diagnosis of AKI depends on the increase of serum creatinine and/or the decrease of urinary output. Early detection, prevention, and treatment become the key points to improve the prognosis of AKI patients because specific therapies to treat of AKI are still unavailable currently. In order to deepen the understanding of AKI and improve the level of diagnosis and treatment of AKI, this paper focuses on the diagnosis, pathophysiology, and treatment of AKI.

Key words: Acute kidney injury, Pathophysiology, Treatment, Renal replacement therapy

Haitao Liu, Kaijiang Yu. Acute kidney injury: pathophysiology and treatment[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2015, 01(01): 42-47.

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URL: https://icu.cma-cmc.com.cn/EN/10.3877/cma.j.jssn.2096-1537.2015.01.011

https://icu.cma-cmc.com.cn/EN/Y2015/V01/I01/42

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References 24

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分期	Scr标准	尿量标准
1	基础值的1.5～1.9倍或增加≥26.5 μmol/L	<0.5 ml/（kg?h），6～12 h
2	基础值的2.0～2.9倍	<0.5 ml/（kg?h），≥12 h
3	基础值的3倍，或肌酐升高至≥353.6 μmol/L；（或）开始进行肾脏替代治疗；（或）年龄<18岁时，eGFR下降<35 ml/（min?1.73 m²）	<0.5 ml/（kg?h），>24 h或无尿≥12 h

分期	Scr标准	尿量标准
1	基础值的1.5～1.9倍或增加≥26.5 μmol/L	<0.5 ml/（kg?h），6～12 h
2	基础值的2.0～2.9倍	<0.5 ml/（kg?h），≥12 h
3	基础值的3倍，或肌酐升高至≥353.6 μmol/L；（或）开始进行肾脏替代治疗；（或）年龄<18岁时，eGFR下降<35 ml/（min?1.73 m²）	<0.5 ml/（kg?h），>24 h或无尿≥12 h

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