With the progress of medical technology, the popularization of intensive care unit (ICU), and the wide application of advanced monitoring and treatment instruments in clinical practice, critical care medicine is developing everyday, the number of ICU patients is increasing everyday. However, due to the neglect of physical and mental health of patients and their family members after being transferred out of ICU, patients will suffer from physiological, cognitive and psychological disorders. The health status and life qualities of this large group are not as good as we imagined. The concept of post-intensive care syndrome (PICS), a new term proposed by the American critical care society at the 2010 global conference on critical care, has attracted the attention of researchers worldwide. This review will include the concept of post-ICU syndrome, clinical manifestations, influencing factors, evaluation tools, and intervention measures, to provide information for scientific researchers on the study of PICS, and to expand the idea of prevention and treatment of PICS for medical staff.