The benefit of enteral nutrition in critically ill patients has been demonstrated by several studies. Initiating nutrition support in hemodynamically unstable ICU patients can be a challenging endeavor. There are many controversies about supplying of EN in critically ill patients with vasopressor. Concerns about early EN (EEN) in patients on vasopressors are still present due to possibility of acute mesenteric ischemia (AMI) and nonocclusive bowel necrosis (NOBN). For these patients, the assessment and monitoring of hemodynamic status are crucial. This paper discusses the monitoring of hemodynamic status during the implementation of enteral nutrition, such as the effect of vasopressor drug dose and perfusion index on gastrointestinal tract, and proposes the importance of monitoring and evaluation of hemodynamic status.