Abstract:

Sepsis is a syndrome characterized by uncontrolled host inflammation triggered by severe infection, often leads to multi-organ dysfunction. Pyroptosis is a programmed cell death mechanism that significantly amplifies the inflammatory cascade during sepsis. Gasdermin proteins, discovered recently, play pivotal roles in executing this inflammatory cell death process by creating pores in the cytoplasmic membrane upon cleavage, activated through both canonical and non-canonical pyroptosis pathways. Enhancing our comprehension of Gasdermin proteins is crucial to grasp their contribution to the uncontrolled inflammatory response in sepsis. Such an understanding is vital to unravel the connection between pyroptosis-driven inflammation and the onset and progression of sepsis. Additionally, it would elucidate the role of Gasdermin proteins in the pathophysiological mechanism of sepsis, thereby providing new insights for the subsequent regulation and treatment of the inflammatory response in sepsis. We reviewed the Gasdermin protein family's role and mechanisms in pyroptosis in sepsis. It also highlights the potential for Gasdermins as targets for immune modulation in combating inflammation in sepsis.

Key words: Sepsis, Pyroptosis, Gasdermin protein family, Inflammatory response