Cell migration：a key mechanism of gut-lung interaction in sepsis

doi:10.3877/cma.j.issn.2096-1537.2025.02.012

Abstract

Abstract:

During the progression of sepsis，disruption of the intestinal barrier function and dysregulation of the immune system can trigger dysregulated inflammatory responses both locally in the gut and systemically.This leads to aberrant activation and migration of immune cells，thereby exacerbating pulmonary inflammation and tissue damage.Conversely，the onset of acute lung injury may further compromise the intestinal mucosal barrier，forming a detrimental bidirectional vicious cycle.Therefore，elucidating the mechanisms of immune cell migration and their role in gut-lung crosstalk can provide novel therapeutic targets for sepsis-induced acute respiratory distress syndrome.

Key words: Sepsis, “Gut-lung” axis, Acute respirarory distress syndrome

Jiancheng Zhang, Bing Xie, You Shang. Cell migration：a key mechanism of gut-lung interaction in sepsis[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2025, 11(02): 163-166.

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