The role of the PD-1/PD-L1 pathway in organ dysfunction caused by sepsis

doi:10.3877/cma.j.issn.2096-1537.2025.02.018

Abstract

Abstract:

Sepsis is the result of the interaction of multiple factors such as inflammation，immune activation，immune suppression，and hypoxia.Sepsis can lead to multiple organ dysfunction and has a high mortality rate.The clinical development of sepsis is often affected by multiple factors.PD-L1 has been proven to be a new prognostic biomarker for predicting mortality in sepsis.However，its role in sepsis-induced organ function The role of the PD-1/PD-L1 pathway in sepsis has not yet been determined.This review mainly introduces the latest research progress on the role of the PD-1/PD-L1 pathway in causing organ dysfunction in the progression of sepsis.To investigate whether blocking PD-1/PD-L1 pathway can improve organ dysfunction in patients with sepsis.

Key words: Sepsis, Programmed death-1, Programmed death ligand-1, Organ dysfunction

Youjia Zhang, Mingyue Ding, Zhiqi Liu, Shuaige Zheng, Shihao Liu, Bingyu Qin. The role of the PD-1/PD-L1 pathway in organ dysfunction caused by sepsis[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2025, 11(02): 198-203.

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URL: https://icu.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2096-1537.2025.02.018

https://icu.cma-cmc.com.cn/EN/Y2025/V11/I02/198

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