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中华重症医学电子杂志 ›› 2016, Vol. 02 ›› Issue (04) : 247 -253. doi: 10.3877/cma.j.issn.2096-1537.2016.04.005

所属专题: 重症医学 文献

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急性呼吸窘迫综合征:未来是否还需要机械通气?
李旭1, 马晓春1,()   
  1. 1. 110001 沈阳,中国医科大学附属第一医院重症医学科
  • 收稿日期:2016-11-09 出版日期:2016-11-28
  • 通信作者: 马晓春

Do we need mechanical ventilation to treat acute respiratory distress syndrom in the future?

Xu Li1, Xiaochun Ma1,()   

  1. 1. Department of Critical Care Medicine, The First Affiliated Hospital of China Medical University, Shenyang 110001, China
  • Received:2016-11-09 Published:2016-11-28
  • Corresponding author: Xiaochun Ma
  • About author:
    Corresponding author: Ma Xiaochun, Email:
引用本文:

李旭, 马晓春. 急性呼吸窘迫综合征:未来是否还需要机械通气?[J/OL]. 中华重症医学电子杂志, 2016, 02(04): 247-253.

Xu Li, Xiaochun Ma. Do we need mechanical ventilation to treat acute respiratory distress syndrom in the future?[J/OL]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2016, 02(04): 247-253.

急性呼吸窘迫综合征(acute respiratory distress syndrom,ARDS)是急性呼吸衰竭最严重的形式,机械通气是ARDS患者的基础治疗,主要作用是改善氧合和清除二氧化碳,并为重症患者其他器官功能支持和机体恢复提供保障。然而,随着有创机械通气的应用,人们逐渐意识到它对患者可能产生副损伤,尤其是呼吸机相关性肺损伤。基于此,人们致力于探索ARDS患者有创机械通气的替代手段,如无创通气、高流量鼻导管氧疗、体外膜肺氧合、体外二氧化碳清除及一些药物治疗手段。由于ARDS患者基础条件和病变的异质性,在某类ARDS患者或在ARDS的某个阶段,非有创机械通气的治疗模式也能满足患者的需求,但在多数ARDS患者有创机械通气仍是不可替代的。

Acute respiratory distress syndrome (ARDS) is one of the most severe type of acute respiratory failure. Mechanical ventilation (MV) is the cornerstone therapy for ARDS patients, for its important effects on improving oxygenation and carbon dioxide (CO2) excretion, and also for its supporting effects for other organs in critically ill patients. However, with invasive MV being widely applied, its potential harm was also recognized, especially for ventilator-induced lung injury (VILI). In the past few years, there has been a consistent effort to develop alternative strategies to completely avoid the need for invasive MV. In particular, several studies have explored the feasibility and efficacy of non-invasive MV、high flow nasal cannula oxygen therapy、extracorporeal oxygenation、carbon dioxide removal and some pharmacological therapies and so on. As ARDS is a heterogeneous disease , therapeutic methods instead of invasive MV might be effective for some patients in some clinical sinario during some stage of ARDS. But still, invasive MV remains the mainstay of care for most of the patients with ARDS.

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