分析脓毒性休克的研究分布、经典文献、热点及前沿等。

以中国生物医学文献数据库（CBM）中1977年1月1日至2017年12月31日年发表的脓毒性休克研究论文为对象，借助可视化分析软件Ucinet 6，获得我国针对脓毒性休克研究文献的省份和核心作者合作图谱、研究关键词的出现频率及聚类分析等。

国内近年来针对脓毒性休克的研究呈现逐年递增趋势，但研究力量主要集中在广东、北京、江苏等中东部经济相对发达地区，而内蒙古、青海、西藏等经济相对欠发达地区研究较少。核心研究团队主要为刘大为教授、杜斌教授所在的北京协和医院和邱海波教授所在的东南大学附属中大医院研究团队。对于研究热点的统计发现，目前研究热点较为混乱，主要集中在脓毒性休克的治疗、护理和预后等，而针对脓毒性休克的致病因素、检验手段、病理过程、微循环等研究较少。而且各省市之间，各医院之间很少有协作研究。

近十年每年针对脓毒性休克的研究文献均在400篇以上，研究主要集中在中东部省份的以重症医学科为优势科室的医院，研究热点主要为脓毒性休克的治疗和预后。今后可加强致病因素、病理过程等研究，并形成跨省市、多学科交叉研究。

To analyze the research distribution, classic literature, hotspots and frontiers of septic shock.

Studies that described septic shock published in the Chinese Biomedical Literature Database (CBM) from January 1, 1977 to December 31, 2017 were included. And the cooperation map between the provinces and core authors related to septic shock, the frequency of occurrence of research keywords, and cluster analysis were obtained by means of visual analysis software Ucinet 6.

In recent years, the research on septic shock in China has shown an increasing trend year by year, but the research power was mainly concentrated in the relatively developed regions of the central and eastern regions such as Guangdong, Beijing and Jiangsu, while less researches in Inner Mongolia, Qinghai and Tibet that were relatively poor area. The core research team was mainly consisted of Professor Liu Dawei, Professor Du Bin who are located in Peking Union Medical College Hospital, and Professor Qiu Haibo in Zhongda Hospital Southeast University. For the research hotspots, the current research hotspots are confusing. Most studies focused on the treatment, nursing and prognosis of septic shock in recent years, but few studies focused on the pathogenic factors, testing methods, pathological processes and microcirculation of septic shock. And there were few collaborative studies between hospitals across provinces and cities.

There are more than 400 research articles on septic shock in the past decade, which are mainly concentrated in the hospitals of the central and eastern provinces with the Department of Critical Care Medicine and mainly focus on the treatment and prognosis of septic shock. In the future, researches on pathogenic factors and pathological processes should be strengthened, and cross-provincial and multidisciplinary research need to be formed.