Advancements in the research on balance of T helper 17 and regulatory T cells in immunity of acute respiratory distress syndrome

doi:10.3877/cma.j.issn.2096-1537.2019.01.012

Abstract

Abstract:

Acute respiratory distress syndrome (ARDS) is common disease in the clinic which induce a high mortality of 40%. Unbalanced inflammation plays a key role in pathophysiological mechanisms of ARDS development. T helper 17(Th17) and regulatory T (Treg) cells are a pair of CD4⁺ T cell subsets with opposite functions. Th17 cells can mediate inflammatory response while Treg cells can inhibit T cell-mediated inflammation and maintain immune tolerance. The imbalance of these two T cell subsets are exist in ARDS, but the mechanism and understanding of Th17/Treg imbalance remains lack of consensus. In this review, we will focus on the recent ?ndings related to role of Th17/Treg imbalance in immunity regulating in ARDS.

Key words: Acute respiratory distress syndrome, Immune response, T helper 17, Regulatory T cells

Ming Xue, Yingzi Huang, Haibo Qiu, Weiping Yu. Advancements in the research on balance of T helper 17 and regulatory T cells in immunity of acute respiratory distress syndrome[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2019, 05(01): 64-67.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://icu.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2096-1537.2019.01.012

https://icu.cma-cmc.com.cn/EN/Y2019/V05/I01/64

References 22

1	Buregeya E, Fowler RA, Talmor DS, et al. Acute respiratory distress syndrome in the global context [J]. Glob Heart, 2014, 9(3): 289-295.
2	Angus DC, van der Poll T. Severe sepsis and septic shock [J]. N Engl J Med, 2013, 369(9): 840-851.
3	Li JT, Melton AC, Su G, et al. Unexpected role for adaptive αβTh17 cells in acute respiratory distress syndrome [J]. J Immunol, 2015, 195(1): 87-95.
4	Stockinger B, Veldhoen M, Martin B. Th17 T cells: linking innate and adaptive immunity [J]. Semin Immunol, 2007, 19(6): 353-361.
5	Risso K, Kumar G, Ticchioni M, et al. Early infectious acute respiratory distress syndrome is characterized by activation and proliferation of alveolar T-cells [J]. Eur J Clin Microbiol Infect Dis, 2015, 34(6): 1111-1118.
6	Li J, Li M, Su L, et al. Alterations of T helper lymphocyte subpopulations in sepsis, severe sepsis, and septic shock: a prospective observational study [J]. Inflammation, 2015, 38(3): 995-1002.
7	McKinley L, Logar AJ, McAllister F, et al. Regulatory T cells dampen pulmonary inflammation and lung injury in an animal model of pneumocystis pneumonia [J]. J Immunol, 2006, 177(9): 6215-6226.
8	Monneret G, Debard AL, Venet F, et al. Marked elevation of human circulating CD4^＋CD25^＋ regulatory T cells in sepsis-induced immunoparalysis [J]. Crit Care Med, 2003, 31(7): 2068-2071.
9	Adamzik M, Broll J, Steinmann J, et al. An increased alveolar CD4^＋CD25^＋Foxp3^＋ T-regulatory cell ratio in acute respiratory distress syndrome is associated with increased 30-day mortality [J]. Intensive Care Med, 2013, 39(10): 1743-1751.
10	Barbi J, Pardoll D, Pan F. Metabolic control of the Treg/Th17 axis [J]. Immunol Rev, 2013, 252(1): 52-77.
11	Pesce B, Soto L, Sabugo F, et al. Effect of interleukin-6 receptor blockade on the balance between regulatory T cells and T helper type 17 cells in rheumatoid arthritis patients [J]. Clin Exp Immunol, 2013, 171(3): 237-242.
12	Zhou L, Lopes JE, Chong MM, et al. TGF-beta-induced Foxp3 inhibits Th17 cell differentiation by antagonizing RORγ function [J]. Nature, 2008, 453(7192): 236-240.
13	Bettelli E, Korn T, Oukka M. Induction and effector functions of Th17 cells [J]. Nature, 2008, 453(7198): 1051-1057.
14	Korn T, Bettelli E, Gao W, et al. IL-21 initiates an alternative pathway to induce proinflammatory Th17 cells [J]. Nature, 2007, 448(7152): 484-487.
15	Afzali B, Lombardi G, Lechler RI, et al. The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease [J]. Clin Exp Immunol, 2007, 148(1): 32-46.
16	Jia W, Cao L, Yang S, et al. Regulatory T cells are protective in systemic inflammation [J]. PLoS One, 2013, 8(5): e64397.
17	Yu ZX, Ji MS, Yan J, et al. The ratio of Th17/Treg cells as a risk indicator in early acute respiratory distress syndrome [J]. Crit Care, 2015, 19: 82.
18	Leentjens J, Kox M, Rebecca M, et al. Reversal of immunoparalysis in humans in vivo [J]. Am J Respir Crit Care Med, 2012, 186(9): 838-845.
19	Wang D, Huang S, Yuan X, et al. The regulation of the Treg/Th17 balance by mesenchymal stem cells in human systemic lupus erythematosus [J]. Cell Mol Immunol, 2017, 14(5): 423-431.
20	Wilson JG, Liu KD, Zhuo H, et al. Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial [J]. Lancet Respir Med, 2015, 3(1): 24-32.
21	Pesce B, Soto L, Sabugo F, et al. Effect of interleukin-6 receptor blockade on the balance between regulatory T cells and T helper type 17 cells in rheumatoid arthritis patients [J]. Clin Exp Immunol, 2013, 171(3): 237-242.
22	Tanaka T. Can IL-6 blockade rectify imbalance between Tregs and Th17 cells? [J]. Immunotherapy, 2013, 5(7): 695-697.

[1]	Meicen Zhou, Hua Wang, Dezhi Mu. Vaccination timeliness in preterm infants: a review of literature [J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2023, 19(03): 261-266.
[2]	Caiying Wang, Ming He, Shuxin He, Yuhuan Liu, Hongling Yang, Lin Pang. Influencing factors of non- or low-response to hepatitis B vaccine immunity in infants of mothers with hepatitis B virus surface antigen positive [J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2022, 16(06): 377-384.
[3]	Lu Shi, Yuming Huang, Cheng Kou, Kaiyu Qin, Yali Wu, Xiaoyang Ma, Dongmei Xu. Differences of clinical phenotypes and laboratory indexes for couples co-infected with treponema pallidum [J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2022, 16(05): 328-336.
[4]	Lung Transplantation Study Group, Branch of Organ Transplantation of Chinese Medical Association;, National Lung Transplantation Quality Control Center. Selection of lung transplant candidates with COVID-19: Advises from China lung transplant expert group [J]. Chinese Journal of Transplantation(Electronic Edition), 2023, 17(01): 13-16.
[5]	Ting Luo, Shi Zhang. Prognostic analysis of 5 biomarkers for acute respiratory distress syndrome [J]. Chinese Journal of Lung Diseases(Electronic Edition), 2023, 16(04): 471-475.
[6]	Zongjun Hu, Xi Yue, Xia Huang. Effect of bronchopulmonary segments recruitment on the survival of patients with severe acute respiratory distress syndrome [J]. Chinese Journal of Lung Diseases(Electronic Edition), 2022, 15(06): 796-800.
[7]	Jianpeng Wang, Yongshi Liao, Wencong Ding, Chong Li, Rui Chen. Research progress of lncRNA in traumatic brain injury [J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2022, 08(06): 365-370.
[8]	Rui Chen, Hongna Yang, Wei Fang, Xinxin Li, Tiantian Li, Xiaoyi Yu, Yanxue Wang, Wenyu Li. Correlation between the cytokine levels in serum and BALF and intrapulmonary and extrapulmonary ARDS [J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2023, 09(03): 251-258.
[9]	Meiqing Wu, Jin Lin, Meili Duan, Xiaoyan Xue. Effect of high density lipoprotein level on the occurrence of sepsis-related acute respiratory distress syndrome [J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2023, 09(02): 191-197.
[10]	Jieqiong Wang, Huixia Wang, Huiying Zhao, Youzhong An. Regulation of angiotensin converting enzyme 2 on inflammatory injury of human pulmonary microvascular endothelial cells [J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2023, 09(01): 78-83.
[11]	Dongyu Chen, Chun Pan, Yi Yang. Techniques to monitor respiratory effort in acute respiratory distress syndrome [J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2023, 09(01): 84-88.
[12]	Jingen Xia, Shiyu Hu. Application scenario of extracorporeal carbon dioxide removal technology in Intensive Care Unit [J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2023, 09(01): 40-45.
[13]	Chengfen Yin, Lei Xu. Talk about the timing of prone position ventilation again [J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2023, 09(01): 9-13.
[14]	Yumei Wang, Yan Wang, Yimin Zhou, Mingyue Miao, Yanlin Yang, Linlin Zhang, Ming Xu, Jianxin Zhou. Application of regional recruitment-to-inflation ratio monitored by electrical impedance tomography in the models of acute respiratory distress syndrome [J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2022, 08(04): 360-366.
[15]	Chengfen Yin, Lei Xu. Settings of mechanical ventilation during V-V ECMO support in ARDS patients [J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2022, 08(04): 378-383.

Please choose a citation manager

Content to export