Mechanisms of directional differentiation of mesenchymal stem cells in ARDS

doi:10.3877/cma.j.issn.2096-1537.2019.03.010

Abstract

Abstract:

Acute respiratory distress syndrome (ARDS) is a syndrome of acute hypoxemic respiratory failure. The pathologic hallmark of ARDS is diffuse alveolar damage, with an injury to both capillary endothelial and alveolar epithelial. Effective repair of alveolar epithelial cells is one of the key therapeutic targets of the treatment for ARDS. With the potential of multi-directional differentiation into endothelial and epithelial cells, mesenchymal stem cells (MSCs) can restore lung structure and protect pulmonary function. The current review focuses on the mechanisms and regulatory factors that influent MSC-directed differentiation and provides further research directions in the treatment of ARDS.

Key words: Mesenchymal stem cells, Directional differentiation, Acute respiratory distress syndrome

Xiwen Zhang, Fengmei Guo, Haibo Qiu. Mechanisms of directional differentiation of mesenchymal stem cells in ARDS[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2019, 05(03): 258-263.

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URL: https://icu.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2096-1537.2019.03.010

https://icu.cma-cmc.com.cn/EN/Y2019/V05/I03/258

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