Efficacy and safety analysis of Ceftazidime-Avibatam in carbapene-resistant Klebsiella pneumoniae infected patients with septic shock

doi:10.3877/cma.j.issn.2096-1537.2021.01.013

Abstract

Abstract:

Objective

To investigate efficacy and safety of Ceftazidime-Avibactam (CZA) in the treatment of septic shock patients infected by carbapenem-resistant Klebsiella pneumoniae (CRKP).

Methods

Clinical data of 4 patients with septic shock caused by CRKP infection who were treated with CZA was retrospectively analyzed. Sequential organ failure assessment (SOFA) score before and after CZA treatment was collected for clinical efficacy and side effect assessment.

Results

Among these 4 patients, 2 were female and 2 were male, aged 72-79 years. Klebsiella pneumoniae was cultured from alveolar lavage fluid, drainaged bile or blood samples, respectively. All cultures of Klebsiella pneumoniae were carbapenem-resistent but sensitive to CZA. After CZA prescription, SOFA score, clinical manifestations and inflammatory biomarkers of these patients were significantly improved and they all discharged home. No side effects related to CZA were reported.

Conclusion

CZA is effective and safe for septic shock patients infected by carbapenem resistant Klebsiella pneumoniae.

Key words: Carbapenem-resistant Klebsiella pneumoniae, Septic shock, Ceftazidime-Avibatan

He Sun, Chunfeng He, Xiaodong Wu, Huize Han, Yi Shi, Qiang Li. Efficacy and safety analysis of Ceftazidime-Avibatam in carbapene-resistant Klebsiella pneumoniae infected patients with septic shock[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2021, 07(01): 76-80.

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URL: https://icu.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2096-1537.2021.01.013

https://icu.cma-cmc.com.cn/EN/Y2021/V07/I01/76

Figures/Tables 3

References 11

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病例	CRP（mg/L)		PCT(ng/ml)		IL-6(pg/ml)		WBC(×10⁹/L)		NE%		D-二聚体(mg/L)
病例	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后		治疗前	治疗后
1	116.9	13.9	7.10	0.44	656.50	17.90	8.5	7.8	85.3	63.5	12.7		0.5
2	>150	20.0	88.00	0.22	3062.00	12.76	28.7	4.6	97.7	56.0	14.1		9.1
3	90.5	32.3	0.26	0.12	148.80	5.87	2.5	5.9	92.3	84.7	3.7		3.2
4	11.6	<5	0.08	0.03	31.97	17.54	18.4	8.0	91.5	75.3	0.7		0.4

病例	CRP（mg/L)		PCT(ng/ml)		IL-6(pg/ml)		WBC(×10⁹/L)		NE%		D-二聚体(mg/L)
病例	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后		治疗前	治疗后
1	116.9	13.9	7.10	0.44	656.50	17.90	8.5	7.8	85.3	63.5	12.7		0.5
2	>150	20.0	88.00	0.22	3062.00	12.76	28.7	4.6	97.7	56.0	14.1		9.1
3	90.5	32.3	0.26	0.12	148.80	5.87	2.5	5.9	92.3	84.7	3.7		3.2
4	11.6	<5	0.08	0.03	31.97	17.54	18.4	8.0	91.5	75.3	0.7		0.4

病例	SOFA评分(分）		氧合指数（mmHg)		转归
病例	治疗前	治疗后	治疗前	治疗后	转归
1	7	4	233	333	好转
2	13	5	80	265	好转
3	10	5	115	250	好转
4	9	3	166	255	好转

病例	SOFA评分(分）		氧合指数（mmHg)		转归
病例	治疗前	治疗后	治疗前	治疗后	转归
1	7	4	233	333	好转
2	13	5	80	265	好转
3	10	5	115	250	好转
4	9	3	166	255	好转

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