Sepsis is common in patients with infection, especially in those ones admitted into intensive care unit (ICU). Studies have found that the incidence of sepsis is on the raise. Despite better understanding of the pathogenesis and advances in mordern techonlogy of supporting therapy have led to an improved outcome of individuals suffering from sepsis , the total number of deaths from sespis is increasing. Even survived from the disease, the life quality of the patients may decrease obviously bacause of the decline of physical conditions, social function, role emotional, etc. Many septic patients are hospitalized in ICUs as they complicated with organ dysfunction/failure, which would bring about tremendous consumption of health resources and dramatic disease burdens to their families and our society. We will summarize the incidence and outcome of sepsis for the purpose of further understanding of the disease and providing evidence for health care resource allocation.