Critical and neurointensive care is an important branch of critical care medicine, including primary nervous system diseases, such as severe trauma brain injury, stroke, subarachnoid hemorrhage and non-primary diseases of nervous system with involvement brain dysfunction which induced by shock, severe sepsis, and ARDS et al, during the medical process. The pathophysiological changes of critical and neurointensive care patients are complicated, and often combine with multiple system and organ dysfunction. The brain interacted with heart, lung, kidney, gastrointestinal tract, liver, pancreas, adrenal gland and other organs. Cross-talk usually exists in the process of the disease. Understanding the interaction between brain and external organs rather than taking stop-gap measures, is helpful in recognition of the nature of diseases and decision-making, whereafter up to precise treatment.