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Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition) ›› 2024, Vol. 10 ›› Issue (02): 108-112. doi: 10.3877/cma.j.issn.2096-1537.2024.02.003

• Expert Opinion • Previous Articles    

Muscle relaxants titration in patients with acute respiratory distress syndrome: necessity and feasibility

Yue Liu1, Chun Pan1,()   

  1. 1. Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, Southeast University, Nanjing 210009, China
  • Received:2023-07-25 Online:2024-05-28 Published:2024-06-26
  • Contact: Chun Pan

Abstract:

Patients diagnosed with acute respiratory distress syndrome (ARDS) often face the dilemma of excessive respiratory drive. Muscle relaxation therapy is an effective means to avoid diaphragm dysfunction that may be caused by excessive respiratory drive. However, due to the abuse of muscle relaxants in the treatment of ARDS, the latest ESICM guidelines point out that the routine use of muscle relaxants in the treatment of ARDS is not recommended to reduce mortality. Therefore, in the clinical treatment of ARDS, the dose of muscle relaxation should be titrated for patients with indications of muscle relaxation, and the appropriate depth of muscle relaxation should be carefully selected so that muscle relaxation treatment can help improve the prognosis of patients. Currently, the depth of muscle relaxation can be monitored through non-invasive and invasive means, so as to avoid the harm caused by blind muscle relaxation and realize protective ventilation of the diaphragm.

Key words: Acute respiratory distress syndrome, Nerve blocking drugs, Respiratory mechanics, Individualized therapy

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