Abstract:

Acute respiratory distress syndrome (ARDS) is a clinical syndrome characterized by diffuse inflammatory alveolar and pulmonary capillary injury caused by both pulmonary and extrapulmonary factors. Due to the complexity of the pathogenesis and widespread heterogeneity at the cellular level, traditional sequencing techniques, which use many cells or tissues as study samples, reflect the overall transcriptomic characteristics of cells but cannot capture the diversity of cellular subgroups and individual cell heterogeneity. This limitation hinders the exploration and application of potential disease targets. Single-cell sequencing provides a new approach to investigate the unique gene expression patterns and molecular mechanisms of individual cells in ARDS. It is crucial for understanding the pathogenesis, clinical features, and identification of potential therapeutic targets in ARDS. This review offers additional insights into the application of single cell sequencing in ARDS, providing a more solid foundation for research in this field.

Key words: Single-cell sequencing, Immune cells, Acute respiratory distress syndrome