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中华重症医学电子杂志 ›› 2024, Vol. 10 ›› Issue (01) : 79 -84. doi: 10.3877/cma.j.issn.2096-1537.2024.01.013

综述

急性呼吸窘迫综合征中巨噬细胞死亡方式的研究进展
陈含冰1, 储翠林1, 邱海波1,()   
  1. 1. 210009 南京,江苏省重症医学重点实验室 东南大学附属中大医院重症医学科
  • 收稿日期:2022-07-17 出版日期:2024-02-28
  • 通信作者: 邱海波
  • 基金资助:
    国家自然科学基金重点项目(81930058); 江苏省重症医学重点实验室项目(BM2020004)

New insights in macrophage dying mechanisms in acute respiratory distress syndrome

Hanbing Chen1, Cuilin Chu1, Haibo Qiu1,()   

  1. 1. Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China
  • Received:2022-07-17 Published:2024-02-28
  • Corresponding author: Haibo Qiu
引用本文:

陈含冰, 储翠林, 邱海波. 急性呼吸窘迫综合征中巨噬细胞死亡方式的研究进展[J/OL]. 中华重症医学电子杂志, 2024, 10(01): 79-84.

Hanbing Chen, Cuilin Chu, Haibo Qiu. New insights in macrophage dying mechanisms in acute respiratory distress syndrome[J/OL]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2024, 10(01): 79-84.

急性肺损伤/急性呼吸窘迫综合征(ALI/ARDS)的根本发病机制是各种因素引起的机体促炎和抗炎反应的失衡,从而导致炎症反应的失控,并引起一系列病理生理的改变。巨噬细胞可通过包括凋亡、自噬、焦亡、坏死等不同的死亡形式在肺部炎症的进展中发挥重要作用。探究巨噬细胞在ALI/ARDS中的具体死亡机制并寻找可用于药物治疗的潜在靶点对于ALI/ARDS的诊断和治疗具有重要意义。本文就关于ALI/ARDS中巨噬细胞的不同死亡方式进行综述,以期为ALI/ARDS开发新的治疗方式提供依据。

The fundamental pathogenesis of acute lung injury/acute respiratory distress syndrome (ALI/ARDS) lies in the imbalance between proinflammatory and anti-inflammatory responses caused by various etiology, which leads to uncontrolled inflammatory response and a series of pathophysiological changes. Macrophages play an important role in the progression of lung inflammation through different mechanism, including apoptosis, autophagy, pyroptosis, necrosis and so on. It is of great significance to explore specific mechanism of macrophages in ALI/ARDS and find potential targets for drug therapy. This article reviews such mechanisms in ALI/ARDS, in order to provide thoughts for development of new treatment for ALI/ARDS.

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