1例特重度烧伤患者，烧伤面积约85%（深Ⅱ~Ⅲ度），烧伤后创面急性大量渗出、持续19 d行连续性肾脏替代治疗（CRRT），继发创面、肺部、血流及消化道的泛耐药鲍曼不动杆菌感染，合并多器官功能衰竭，予以积极处理创面，仍有反复感染，多次启动以多黏菌素B为基础的联合治疗方案，并通过治疗药物监测（TDM）在治疗期间多次监测多黏菌素B的药物浓度，合理调整给药剂量，在患者行左小腿截肢术后，体质量发生变化，药物浓度较前偏高，后通过剂量调整，最终使患者感染得到有效控制。

One patient with extremely severe burn, with an area of about 85% (deep second to third degree), received continuous renal replacement therapy (CRRT) for 19 days. This was prompted by a sudden and significant release of fluid from the burn wound, followed by an infection caused by pan-drug resistant Acinetobacter baumannii. The infection affected various parts of the body, including the wound, lungs, bloodstream, and digestive tract, leading to multiple organ failure. Despite active treatment of the wound, the patient experienced recurring infections and required multiple rounds of combined treatment involving polymyxin B. Through therapeutic drug monitoring (TDM), the drug concentration of polymyxin B was monitored many times throughout treatment, allowing for appropriate dosage adjustment. After the amputation of the left leg, there was a change in body mass and an increase in drug concentration. Finally, through the adjustment of the dosage, the patient's infection was well controled.