Advances on NK cells in immunity dysfunction caused by sepsis

doi:10.3877/cma.j.issn.2096-1537.2019.02.020

Abstract

Abstract:

Sepsis is a life-threatening organ dysfunction caused by dysregulated host responses to infection. Immune responses play a crucial role in the development of sepsis. Thus regulation of them can be a novel therapeutic target. Natural killer (NK) cells are large granular lymphocytes of innate immunity. They can not only initiate and amplify inflammation by interacting with other cells of innate immunity, but also regulate infection through adaptive immunity. NK cells are of great importance in the pathogenesis of sepsis. Accurate knowledge of how NK cells functions in sepsis may provide a better understanding of sepsis. Reasonable immunoregulation of NK cells can be a novel therapy of sepsis.

Key words: NK cells, Sepsis, Immunity dysfunction, Immunoregulation

Zihan Hu, Jianfeng Xie, Yi Yang. Advances on NK cells in immunity dysfunction caused by sepsis[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2019, 05(02): 194-198.

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URL: https://icu.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2096-1537.2019.02.020

https://icu.cma-cmc.com.cn/EN/Y2019/V05/I02/194

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