Application of single cell sequencing technology in the study of sepsis immunity

doi:10.3877/cma.j.issn.2096-1537.2024.03.012

Abstract

Abstract:

Sepsis is a clinical syndrome with a high mortality rate, and despite the development and advancement of multidisciplinary approaches, sepsis can progress to fatal organ failure. In recent years, the rapid development of single-cell sequencing technology has provided a new technical support for the exploration of the pathophysiological mechanism of sepsis, especially the application in immunology has made the precise prevention and treatment of sepsis possible. This review reviewed relevant studies in recent years, described the occurrence and development of sepsis and sepsis-induced immunosuppression, introduced the application progress of single cell sequencing technology in sepsis and sepsis-induced immunosuppression research, and aimed to explore the possibility of future application of single cell sequencing technology in the precision treatment of sepsis.

Key words: Sepsis, Single-cell RNA sequencing, Immunosuppression, Precision medicine

Shenglin Su, Jinlan Ma, Hongming Yu, Xiaojun Yang. Application of single cell sequencing technology in the study of sepsis immunity[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2024, 10(03): 279-286.

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URL: https://icu.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2096-1537.2024.03.012

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