Progress in research of phenotypes and endotypes in acute respiratory distress syndrome

doi:10.3877/cma.j.issn.2096-1537.2020.02.022

Abstract

Abstract:

Acute respiratory distress syndrome (ARDS) is a life-threatening respiratory failure that can result from a variety of causes. Because of the heterogeneity in etiology, pathology, pathogenesis, clinical manifestations, imaging manifestations, and gene characteristics of ARDS, there are different phenotypes or endotypes of ARDS. This paper reviews the relevant research results in recent years, and the progress in research of different phenotypes and endotypes in ARDS, with an aim to help intensive care unit (ICU) doctors to better understand the phenotypes and endotypes of ARDS and provide some reference for ARDS precision medicine in future.

Key words: Respiratory distress syndrome, adult, Heterogeneity, Phenotype, Endotypes, Biological markers, Precision medicine

Ying Shi, Xiangrong Zuo, Quan Cao. Progress in research of phenotypes and endotypes in acute respiratory distress syndrome[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2020, 06(02): 215-222.

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